Recombinant antibodies for immunotherapy / edited by Melvyn Little.

Format:

Book

Contributor:

Little, Melvyn, 1945-

Language:

English

Subjects (All):

Monoclonal antibodies--Therapeutic use.

Monoclonal antibodies.

Immunotherapy--methods.

Antibodies, Monoclonal--therapeutic use.

Recombinant Proteins--therapeutic use.

Medical Subjects:

Immunotherapy--methods.

Antibodies, Monoclonal--therapeutic use.

Recombinant Proteins--therapeutic use.

Physical Description:

xiv, 419 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

New York : Cambridge University Press, 2009.

Contents:

Humanization of recombinant antibodies / José W. Saldanha

Immunogenicity assessment of antibody therapeutics / Philippe Stas ... [et al.]

In vitro screening for antibody immunogenicity / Frank J. Carr and Matthew B. Baker

Antibody libraries from naïve V gene sources / Gerald Beste and David Lowe

Antibodies from IgM libraries / Stefan Knackmuss and Vera Molkenthin

Generation and screening of synthetic human combinatorial antibody library HuCAL GOLD / Ingo M. Klagge

Therapeutic antibodies from XenoMouse transgenic mice / Aya Jakobovits

VelocImmune: immunoglobulin variable region humanized mice / Andrew Murphy

Mechanisms of tumour cell killing by therapeutic antibodies / Ross Stewart and Carl Webster

Optimization of Fc domains to enhance antibody therapeutics / Greg A. Lazar and Aaron K. Chamberlain

Glycoengineered therapeutic antibodies / Peter Brünker, Peter Sondermann, and Pablo Umaña

Monoclonal antibodies for the delivery of cytotoxic drugs / David J. King

Immunotherapy with radio-immune conjugates / Christina A. Kousparou and Agamemnon A. Epenetos

Immunotherapeutic antibody fusion proteins / Nigel S. Courtenay-Luck and David Jones

Alternative antibody formats / Fabrice Le Gall and Melvyn Little

Single-domain antibodies / Serge Muyldermans, Gholamreza Hassanzadeh Ghassabeh, and Dirk Saerens

Engineering of non-CDR loops in immunoglobulin domains / Florian Rüker and Gordana Wozniak-Knopp

Alternative scaffolds: expanding the options of antibodies / Andreas Plückthun

Polymer fusions to increase antibody half-lives: PEGylation and other modifications / Sam P. Heywood and David P. Humphreys

Extending antibody half-lives with albumin / Jan Terje Andersen and Inger Sandlie

A stem cell-based platform for the discovery and development of antitumor therapeutic antibodies to novel targets / Jennie P. Mather ... [et al.]

Antibody directed enzyme prodrug therapy (ADEPT) / Helen L. Lowe ... [et al.]

Immune privilege and tolerance - therapeutic antibody approaches / Daron Forman ... [et al.]

Antibody therapeutics: business achievements and business outlook / Christophe Bourrilly.

Notes:

Includes bibliographical references and index.

ISBN:

9780521887328

0521887321

OCLC:

263294948