Thyroid and heart failure : from pathophysiology to clinics / Giorgio Iervasi, Alessandro Pingitore, editors ; forewords by Paul W. Ladenson, Attilio Maseri.

Format:

• Book

Contributor:

• Iervasi, Giorgio.
• Pingitore, Alessandro.

Language:

English

Subjects (All):

• Heart failure--Etiology.
• Hyperthyroidism--Complications.
• Heart Failure--etiology.
• Heart Failure--physiopathology.
• Heart Failure--therapy.
• Hyperthyroidism--complications.
• Hypothyroidism--complications.
• Thyroid Hormones--metabolism.
• Hyperthyroidism.
• Heart failure.
• Diseases--Causes and theories of causation.

Medical Subjects:

• Heart Failure--etiology.
• Heart Failure--physiopathology.
• Heart Failure--therapy.
• Hyperthyroidism--complications.
• Hypothyroidism--complications.
• Thyroid Hormones--metabolism.

Physical Description:

xxi, 264 pages : illustrations (some color) ; 27 cm

Place of Publication:

[Milan ;] [New York] : Springer, [2009]

Summary:

Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid-heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.

Contents:

• Section I Heart Failure and Thyroid: General Aspects
• 1 Heart Failure: From Epidemiology to Pathophysiology / Antonio L'Abbate 3
• 2 Neuroendocrine Control of the Cardiovascular System in Heart Failure / Claudio Ceconi, Roberto Ferrari 13
• 3 Cardiac Morphology and Function in Mild Hypothyroidism / Bernadette Biondi 21
• 4 Cardiovascular Hemodynamics and Work Capacity in Thyroid Dysfunction / George J. Kahaly 31
• Section II Basic Aspects of Thyroid Hormone and Cardiovascular System Interrelationships in Normal and in Failing Heart
• 5 Mechanism of Action of Thyroid Hormone on the Cardiac Vascular System / Wolfgang H. Dillmann 45
• 6 Cardiac Functional Effects of 3-Iodothyronamine, a New Endogenous Thyroid Hormone Derivative / Riccardo Zucchi, Sandra Ghelardoni, Grazia Chiellini 55
• 7 Cardiac Thyroid-Hormone Deiodinative Pathways in Ventricular Hypertrophy and Heart Failure / Warner S. Simonides 67
• 8 Thyroid Hormone Receptor Signaling in Normal and Failing Heart / Koichiro Kinugawa, Mark Y. Jeong, Michael R. Bristow, Carlin S. Long 79
• 9 Pharmacological Effects of Amiodarone and Dronedarone on Cardiac Thyroid Hormone Receptors / Wilmar M. Wiersinga 89
• 10 Changes in Thyroid Hormone Metabolism and Gene Expression in the Failing Heart: Therapeutic Implications / Sara Danzi, Irwin Klein 97
• 11 Thyroid-Hormone-Regulated Cardiac Metabolism in Normal and Failing Heart / Michael A. Portman 109
• 12 Cardiac Myocyte and Vascular Remodeling in Altered Thyroid Conditions / Yuefeng Chen, A. Martin Gerdes 119
• 13 Thyroid Hormone and Ischemic Myocardium / Constantinos Pantos, Iordanis Mourouzis, Dennis V. Cokkinos 131
• Section III Clinical Aspects
• 14 Thyroid and Cardiovascular Risk / Avantika C. Waring, Anne R. Cappola 151
• 15 Relationship Between Subclinical Thyroid Dysfunction and Heart Failure and Mortality / Reto Auer, Nicolas Rodondi 167
• 16 Low Triiodothyronine Syndrome as a Powerful Predictor of Death in Heart Failure / Giorgio Iervasi, Laura Sabatino, Giuseppina Nicolini 179
• 17 Thyroid, Renal Function, and Cardiac Outcome / Carmine Zoccali, Francesca Mallamaci 191
• 18 Low Triiodothyronine Syndrome and Depression in Patients with Chronic Heart Failure / Robertas Bunevičius 203
• Section IV Treatment: Present and Future Options
• 19 Treatment Options for Primary Thyroid Disease in Patients with Heart Failure / Anthony Toft, Kate Gaskell 215
• 20 Synthetic Thyroid Hormone and Thyroid Hormone Analogues for Treatment of Heart Failure / Alessandro Pingitore, Vincenzo Lionetti, Francesca Fiorini 225
• 21 Thyroid Hormone Supplementation for Infants and Children Undergoing Cardiopulmonary Bypass for Cardiac Surgery / Aaron K. Olson, Michael A. Portman 243
• 22 New Approaches for Treating Heart Disease by Modulating Thyroid Hormone Signaling Using Gene Therapy Approaches / Mark Davis, Maria Giovanna Trivieri, Peter H. Backx 249.

Notes:

Includes bibliographical references and index.

ISBN:

• 9788847011427
• 8847011426

OCLC:

429586367