Oxidative neural injury / Sigrid C. Veasey, editor.

Format:

Book

Contributor:

Veasey, Sigrid C.

Series:

Contemporary clinical neuroscience

Language:

English

Subjects (All):

Nervous system--Degeneration.

Nervous system.

Nervous system--Wounds and injuries.

Oxidative stress.

Nervous System--pathology.

Oxidative Stress.

Medical Subjects:

Nervous System--pathology.

Oxidative Stress.

Physical Description:

xiii, 215 pages : illustrations ; 24 cm.

Place of Publication:

[New York] : Humana Press, [2009]

Summary:

Oxidative changes are observed in healthy aging of the nervous system, neuro-degenerative processes and other forms of neural injury. At the same time, reactive oxygen species and reactive nitrogen species play critical roles in rapid response signaling, in learning, plasticity and in neuronal homeostasis. How do reactive oxygen and nitrogen molecules play such divergent roles in physiology and pathophysiology? How do these molecules contribute to neural injury, dysfunction and loss? The text Oxidative Neural Injury brings together international experts to systematically describe the biochemistry of reactive oxygen and nitrogen species signaling and then integrate this biochemistry into the neurobiology of redox in learning and plasticity and in healthy aging. This information will serve as the much-needed infrastructure for understanding in a more comprehensive manner how redox modifications contribute to neurodegenerative processes, in both early and late injury. Indeed, it is apparent that the development of effective therapies for neurodegenerative processes will first require a careful understanding of these critical roles of reactive oxygen and nitrogen molecules in neuronal signaling and cellular homeostasis, and this must be complemented with a comprehensive understanding of how reactive oxygen and nitrogen species perturb specific organelle and cellular functions.

Contents:

Section I Redox Regulation of Cell Signaling

Reactive Oxygen Species, Synaptic Plasticity, and Memory / Kenneth T. Kishida, Eric Klann 1

Nitric Oxide Biochemistry: Pathophysiology of Nitric Oxide-Mediated Protein Modifications / Alba Rossi-George, Andrew Gow 29

Section II Pathophysiology of Redox Imbalance

Redox Imbalance in the Endoplasmic Reticulum / Gábor Bánhegyi, Éva Margittai, Miklós Csala, József Mandl 45

Exocytosis, Mitochondrial Injury and Oxidative Stress in Neurodegenerative Diseases / Mark P. Zanin, Damien J. Keating 65

Neuronal Vulnerability to Oxidative Damage in Aging / Eitan Okun, Mark P. Mattson 83

Section III Oxidative Injury in Neurodegenerative Processes

Ischemia-Reperfusion Induces ROS Production from Three Distinct Sources / Rosemary H. Milton, Andrey Y. Abramov 97

Alzheimer Disease: Oxidative Stress and Compensatory Responses / Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Hyoung-Gon Lee, Gjumrakch Aliev, Mark A. Smith, George Perry 109

Oxidative Stress Associated Signal Transduction Cascades in Alzheimer Disease / Robert B. Petersen, Akihiko Nunomura, Hyoung-gon Lee, Gemma Casadesus, George Perry, Mark A. Smith, Xiongwei Zhu 121

Nitrated Proteins in the Progression of Alzheimer's Disease: A Proteomics Comparison of Mild Cognitive Impairment and Alzheimer's Disease Brain / Rukhsana Sultana, Renã A. Sowell, D. Allan Butterfield 137

Parkinson's Disease: An Overview of Pathogenesis / Pratap Chand, Irene Litvan 159

Protein Oxidation Triggers the Unfolded Protein Response and Neuronal Injury in Chemically Induced Parkinson Disease / Alison I. Bernstein, Karen L. O'Malley 179

Treating Oxidative Neural Injury: Methionine Sulfoxide Reductase Therapy for Parkinson's Disease / Ramez Wassef, Stefan H. Heinemann, Toshinori Hoshi 193.

Notes:

Includes bibliographical references and index.

ISBN:

9781603273411

1603273417

1603273425

9781603273428

OCLC:

276225926