Animal models of epilepsy : methods and innovations / edited by Scott C. Baraban.

Format:

Book

Contributor:

Baraban, Scott C.

Series:

Neuromethods ; 40.

Springer protocols (Series)

Neuromethods ; 40

Springer protocols

Language:

English

Subjects (All):

Epilepsy--Animal models.

Epilepsy.

Epilepsy in animals.

Models, Animal.

Medical Subjects:

Epilepsy.

Models, Animal.

Physical Description:

xiii, 272 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 27 cm.

Place of Publication:

New York : Humana Press, 2009.

Summary:

With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogoster (fruit flies), Caenorhabdtis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods™ series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field.

Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Contents:

The nematode, Caenorhabditis elegans, as an emerging model for investigating epilepsy / Cody J. Locke, Kim A. Caldwell, and Guy A. Caldwell

The genetics and molecular biology of seizure susceptibility in drosophila / Juan Song and Mark A. Tanouye

The albino Xenopus laevis tadpole as a novel model of developmental seizures / D. Sesath Hewapathirane and Kurt Haas

Zebrafish as a simple vertebrate organism for epilepsy research / Scott C. Baraban

Modeling tuberous sclerosis complex: brain development and hyperexcitability / Devin C. Ess

BK potassium channel mutations affecting neuronal function and epilepsy / David Petrik, Qing H. Chen, and Robert Brenner

Mouse models of benign familial neonatal convulsions (BFNC): mutations in KCNQ (Kv7)genes / Nanda A. Singh ... [et al.]

Interneuron loss as a cause of seizures: lessons from interneuron-deficient mice / Dorothy Jones-Davis, Maria-Elisa Calcagnotto, and Joy Y. Sebe

Imaging seizure propagation in vitro / Andrew J. Trevelyan and Rafael Yuste

Complexity untangled: large-scale realistic computational models in epilepsy / Robert J. Morgan and Ivan Soltesz

Organotypic hippocampal slice cultures as a model of limbic epileptogenesis / Suzanne B. Bausch

Seizure analysis and detection in vivo / Javier Echauz, Stephen Wong, and Brian Litt

Viral vector gene therapy for epilepsy / Stacey B. Foti, Shelley J. Russek, Amy R. Brooks-Kayal, and Thomas J. McCown

Neural stem cells in experimental mesial temporal lobe epilepsy / Michelle M. Kron and Jack M. Parent.

Notes:

Includes bibliographical references and index.

ISBN:

9781603272629

1603272623

OCLC:

401897995