Systems biology and biotechnology of escherichia coli / Sang Yup Lee, editor.

Format:

Book

Contributor:

Yi, Sang-yŏp, 1964-

Language:

English

Subjects (All):

Escherichia coli.

Systems biology.

Systems Biology.

Medical Subjects:

Escherichia coli.

Systems Biology.

Physical Description:

xxi, 462 pages : illustrations ; 25 cm

Place of Publication:

[Dordrecht] : Springer, [2009]

Summary:

Systems biology and Biotechnology of Escherichia coli Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. Escherichia coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered includegenomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms.

This book will be a complete resource for anyone interested in systems biology and biotechnology.

Contents:

1 Genomics, Biological Features, and Biotechnological Applications of Escherichia coli B: "Is B for better?!" / Sung Ho Yoon, Haeyoung Jeong, Soon-Kyeong Kwon, Jihyun F. Kim 1

2 Escherichia coli Genome Engineering and Minimization for the Construction of a Bioengine / Bong Hyun Sung, Jun Hyoung Lee, Sun Chang Kim 19

3 Multi-Omics Data-Driven Systems Biology of E. coli / Nobuyoshi Ishii, Masaru Tomita 41

4 A Medium-Throughput Structural Proteomics Approach Applied to the Genome of E. coli / Allan Matte, Irena Ekiel, Zongchao Jia, Kalle Gehring, Miroslaw Cygler 59

5 Resources for Escherichia coli Systems Biology / Hirotada Mori, Natsuko Yamamoto, Hitomi Dose, Kenji Nakahigashi, Kirill A. Datsenko, Barry L. Wanner 87

6 The Multiple Scientific Disciplines Served by EcoCyc / Peter D. Karp 99

7 Analysis of E. coli Network / Hawoong Jeong 113

8 Sensory Transduction Network of E. coli / Michael Y. Galperin 133

9 Genome-Scale Reconstruction, Modeling, and Simulation of E. coli's Metabolic Network / Adam M. Feist, Ines Thiele, Bernhard O. Palsson 149

10 Kinetic Modeling of E. coli Enzymes: Integration of in vitro Experimental Data / Ekaterina A. Mogilevskaya, Kirill V. Peskov, Eugeniy A. Metelkin, Galina V. Lebedeva, Tatiana Y. Plyusnina, Igor I. Goryanin, Oleg V. Demin 177

11 Dynamic Modeling of the Central Metabolism of E. coli - Linking Metabolite and Regulatory Networks / Timo Hardiman, Karin Lemuth, Martin Siemann-Herzberg, Matthias Reuss 209

12 Genome-Scale Models and the Genetic Basis for E. coli Adaptation / M. Kenyon Applebee, Bernhard O. Palsson 237

13 Organisation of Complex Escherichia coli Promoters / Douglas F. Browning, David C. Grainger, Stephen J. W. Busby 257

14 Plasmid Regulation and Systems-Level Effects on Escherichia coli Metabolism / Dave Siak-Wei Ow, Dong-Yup Lee, Hsiu-Hui Tung, Sue Lin-Chao 273

15 Systems-Level Analysis of Protein Quality in Inclusion Body-Forming Escherichia coli Cells / Elena Garcia-Fruitos, Nuria Gonzalez-Montalban, Monica Martinez-Alonso, Ursula Rinas, Antonio Villaverde 295

16 Mechanistic Challenges and Engineering Applications of Protein Export in E. coli / Eva-Maria Strauch, George Georgiou 327

17 Engineering E. coli Central Metabolism for Enhanced Primary Metabolite Production / George N. Bennett, Ka-Yiu San 351

18 Glucose and Acetate Metabolism in E. coli- System Level Analysis and Biotechnological Applications in Protein Production Processes / Joseph Shiloach, Ursula Rinas 377

19 Performance Characteristics for Sensors and Circuits Used to Program E. coli / Jeffrey J. Tabor, Eli S. Groban, Christopher A. Voigt 401

20 Systems Metabolic Engineering of E. coli / Sang Yup Lee, Jin Hwan Park 441.

Notes:

Includes bibliographical references and index.

ISBN:

9781402093937

1402093934

OCLC:

297801852