Stem cells and cancer / edited by Rebecca G. Bagley, Beverly A. Teicher.

Format:

Book

Contributor:

Bagley, Rebecca G.

Teicher, Beverly A., 1952-

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Stem cells.

Cancer cells.

Cancer--Etiology.

Cancer.

Stem Cells.

Neooplastic Stem Cells.

Neoplasms--etiology.

Medical Subjects:

Stem Cells.

Neooplastic Stem Cells.

Neoplasms--etiology.

Physical Description:

xv, 334 pages, 12 unnumbered pages of plates : illustrations (partly color) ; 27 cm.

Place of Publication:

[New York, N.Y. ;] [London] : Humana Press, [2009]

Summary:

Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease.

This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoechst dye exclusion to recognize 'side populations.' Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic changes that affect therapeutic response and strategies to prevent disease recurrence are challenges have been incorporated into this volume. Stem Cells and Cancer represents a compendium of cutting edge research by experts in the field and will be instrumental in the study of this intriguing line of investigation for many years to come.

Contents:

Part I Introduction to Cancer Stem Cells

1 The Cancer Stem Cell Hypothesis / Kimberly E. Foreman, Paola Rizzo, Clodia Osipo, Lucio Miele 3

2 Tumor Stem Cells and Malignant Cells, One and the Same / Beverly A. Teicher 15

Part II The Stem Cell Niche

3 Mesenchymal Stem Cells in Tumor Stroma / Nicholas J. Sullivan, Brett M. Hall 29

Part III Molecular Pathways and Gene Expression

4 Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal / Adam Yagui-Beltrǹ, Biao He, David M. Jablons 39

5 PTEN in Hematopoietic and Intestinal Stem Cells and Cancer / Jason T. Ross, David H. Scoville, Xi He, Linheng Li 59

6 Transcription Factors in Cancer Stem Cells of the Hematopoietic Lineage / Steffen Koschmieder, Daniel. G Tenen 75

7 Stem Cell Chromatin Patterns and DNA Hypermethylation / Joyce E. Ohm, Stephen B. Baylin 85

8 Plasticity Underlying Multipotent Tumor Stem Cells / Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E.B. Seftor, Mary J.C. Hendrix 99

Part IV Cancer Stem Cells in Solid Tumors

9 Glioma Stem Cells in the Context of Oncogenesis / Johan Bengzon, Elisabet Englund, Leif G. Salford, Xiaolong Fan 115

10 Mouse Mammary Tumor Virus: Stem Cells and Mammary Cancer / Gilbert H. Smith 127

11 Tumor Dormancy, Metastasis, and Cancer Stem Cells / Alysha K. Croker, Jason L. Townson, Alison L. Allan, Ann F. Chambers 141

12 Cancer Stem Cells: Gastrointestinal Cancers / Hideshi Ishii, Naotsugu Haraguchi, Keisuke Ieta, Koshi Mimori, Masaki Mori 155

13 Cancer Stem Cells: Hepatocellular Carcinoma / Thomas Shupe, Bryon E. Petersen 165

14 Cancer Stem Cells: Lung Cancer / Jaclyn Y. Hung 177

15 Cancer Stem Cells: Pancreatic Cancer / Joseph Dosch, Cheong Jun Lee, Diane M. Simeone 185

16 Prostate Stem Cells and Cancer in Animals / Alexander Yu. Nikitin, Melia G. Nafus, Zongxiang Zhou, Chun-Peng Liao, Pradip Roy-Burman 199

17 Prostate Cancer Stem/Progenitor Cells / Sofia Honorio, Hangwen Li, Dean G. Tang 217

18 Adult Prostate Epithelium Renewal, Stem Cells and Cancer / Chiara Grisanzio, Sabina Signoretti 231

19 Stem Cells, Angiogenesis, and Neurogenesis in Tumors / Judith A. Varner 247

Part V Targeting Cancer Stem Cells with Therapy

20 Implications of Cancer Stem Cells for Cancer Therapy / Liang Cheng, Shaobo Zhang, Darrell D. Davidson, Rodolfo Montironi, Antonio Lopez-Beltran 255

21 Targeting Leukemic Stem Cells / Angelika M. Burger 263

22 Targeting Brain Cancer Stem Cells in the Clinic / Gentao Liu, Keith L. Black, John S. Yu 275

23 Critical Roles of Tumorigenic and Migrating Cancer Stem/Progenitor Cells in Cancer Progression and their Therapeutic Implications / Murielle Mimeault, Surinder K. Batra 287

24 Therapeutic Index and the Cancer Stem Cell Paradigm / Vera S. Donnenberg, Albert D. Donnenberg 309.

Notes:

Includes bibliographical references and index.

ISBN:

9781603279321

1603279326

1603279334

9781603279338

OCLC:

318673136