Molecular basis of hematopoiesis / Amittha Wickrema, Barbara Kee, editors.

Format:

Book

Contributor:

Wickrema, Amittha.

Kee, Barbara Lynne, 1966-

Language:

English

Subjects (All):

Hematopoietic stem cells.

Hematopoietic Stem Cells.

Medical Subjects:

Hematopoietic Stem Cells.

Physical Description:

viii, 257 pages, 6 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Place of Publication:

New York : Springer, [2009]

Summary:

Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases.

Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.

Contents:

1 Hematopoietic Stem Cells / Patricia Ernst 1

2 The Road to Commitment: Lineage Restriction Events in Hematopoiesis / Robert Mansson, Sasan Zandi, David Bryder, Mikael Sigvardsson 23

3 Hematopoietic Stem Cell Niches / Anne Wilson, Andreas Trumpp 47

4 Molecular Biology of Erythropoiesis / James Palis 73

5 Development of Megakaryocytes / Nicholas Papadantonakis, Katya Ravid 95

6 Development of Macrophages and Granulocytes / Richard Dahl 127

7 Development of T Lymphocytes / Benjamin A. Schwarz, Avinash Bhandoola 151

8 Development of B Lymphocytes / Steven A. Corfe, Christopher J. Paige 173

9 Development of Natural Killer cells / Francesco Colucci 201

10 Leukemic Stem Cells: New Therapeutic Targets? / Dominique Bonnet 215

11 Targeting Signal Transduction Pathways in Hematopoietic Disorders / Li Zhou, Amit Verma 231.

Notes:

Includes bibliographical references and index.

ISBN:

9780387858159

0387858156

OCLC:

253217085