Metalloproteomics / Eugene A. Permyakov.

Format:

Book

Author/Creator:

Permi︠a︡kov, E. A. (Evgeniĭ Anatolʹevich)

Contributor:

Alumni and Friends Memorial Book Fund.

Series:

Wiley series in protein and peptide science

Language:

English

Subjects (All):

Metalloproteins.

Proteomics.

Metalloproteins--pharmacokinetics.

Protein Binding.

Proteomics--methods.

Medical Subjects:

Metalloproteins--pharmacokinetics.

Protein Binding.

Proteomics--methods.

Physical Description:

xvi, 786 pages, 16 unnumbered pages of plates : illustrations (some color) ; 25 cm.

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, [2009]

Summary:

Metalloproteomics is the large-scale study of metal-binding proteins. These proteins, which represent about one quarter of all the proteins in the Protein Data Bank, play important roles in all biological systems and all biological processes. Metalloproteomics provides the latest information on all major families of metal-binding proteins, including their structural, physico-chemical, and functional properties, enabling readers to better understand these proteins. Moreover, the book demonstrates how understanding the structures, properties, and functions of intracellular and extracellular metal-binding proteins may unlock the key to drug development for the treatment of a myriad of diseases.

Written by Eugene Permyakov, an international expert and pioneer in the structural analysis of metal-binding proteins, the book offers

Theoretical introduction to cation binding

Broad range of methods for investigating the binding of different cations to proteins

Characteristics of interactions of physiologically important cations of Ca, Mg, Zn, Fe, Mn, Co, Cu, Ni, Mo, W, Na, and K with proteins

Detailed considerations of structural and physico-chemical properties of the metal-binding proteins

Interactions of all other metal cations with proteins

Interactions of different types of cations with nucleic acids

Throughout the text, the author integrates principles of proteomics. In addition, detailed examples underscore the role metal-binding proteins play in health and medicine.

Bringing together and analyzing all the latest findings, Metalloproteomics' scope and level of insight are unparalleled. It is recommended for biophysicists, biochemists, enzymologists, cell and molecular biologists, protein and peptide scientists, organic and bioinorganic chemists, and chemical biologists.

Contents:

The complexes of metal cations with low-molecular-mass compounds and of metal cations and proteins

General regularities of the binding of metal cations to proteins

Experimental methods used for studies of the binding of metal cations

Calcium, calcium-binding proteins, and their major families

Interactions of calcium-binding proteins with low-molecular-mass compounds, peptides, proteins, and membranes

Calcium-binding proteins in various systems

The binding of magnesium ions to proteins

The binding of zinc ions to proteins

The binding of copper ions to proteins

Iron-binding proteins

Molybdenum-containing and tungsten-containing proteins

Proteins containing nickel and cobalt

Manganese-containing proteins

Sodium-binding and potassium-binding proteins

Interactions of metal cations with nucleic acids

"Non-physiological" metals.

Notes:

Includes bibliographical references (pages 643-764) and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

9780470392485

0470392487

OCLC:

245512255