Medical biochemistry : human metabolism in health and disease / Miriam D. Rosenthal, Robert H. Glew.

Format:

Book

Author/Creator:

Rosenthal, Miriam D.

Contributor:

Glew, Robert H.

Language:

English

Subjects (All):

Metabolism.

Metabolism--Disorders.

Metabolic Diseases.

Medical Subjects:

Metabolism.

Metabolic Diseases.

Physical Description:

xi, 426 pages : illustrations ; 24 cm

Place of Publication:

Hoboken, NJ : John Wiley & Sons, [2009]

Summary:

Medical Biochemistry enables readers to master the essentials of human metabolism by explaining how metabolic pathways and reactions are connected to human health and disease. Rather than cover all the reactions that human cells and tissues are capable of executing, this text better enables readers to learn core concepts by emphasizing select examples that illustrate the physiologic and pathophysiologic significance of the major metabolic pathways. Designed for medical, dental, and allied health students and professionals, the text emphasizes clinically relevant information, helping readers understand the interrelationships between metabolic pathways and the links between metabolism and the causes, preventions, and cures for human diseases.

A separate chapter is dedicated to each of the key metabolic pathways that constitute human metabolism. Each chapter features a six-part structure that facilitates a clear understanding of the metabolic processes:

1. Major function(s) of the pathway

2. Tissues in which the pathway is active

3. Physiological conditions under which the pathway is most active

4. Reactions that comprise the pathway

5. Regulation of the pathway

6. Examples of human diseases related to the pathway

Throughout the text, simple figures help readers understand how metabolic pathways and reactions work.

This text's concise, easy-to-follow approach helps readers understand and appreciate the functions, constituent reactions, and regulatory aspects of the core pathways that constitute human metabolism and are responsible for maintaining homeostasis and well-being in humans.

Contents:

Introduction to metabolism

Enzymes

Digestion and absorption

Glycolysis

Pyruvate dehydrogenase and the tricarboxylic acid cycle

Electron transport and oxidative phosphorylation

The pentose phosphate pathway

Glycogen

Gluconeogenesis

Fatty acid oxidation and ketones

Fatty acid synthesis

Triacylglycerol transport and metabolism

Ethanol

Phospholipids and sphingolipids

Eicosanoids

Glycolipids and glycoproteins

Cholesterol synthesis and transport

Steroids and bile acids

Nitrogen homeostasis

Amino acids

Sulfur amino acid metabolism

Folate and vitamin B12 in one-carbon metabolism

Purines and pyrimidines

Heme and iron

Integration of metabolism.

Notes:

Includes index.

ISBN:

9780470122372

0470122374

OCLC:

233261246