Telomeres and telomerase in cancer / Keiko Hiyama, editor.

Format:

Book

Contributor:

Hiyama, Keiko.

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Cancer--Molecular aspects.

Cancer.

Telomerase.

Telomere.

Neoplasms--microbiology.

Medical Subjects:

Neoplasms--microbiology.

Telomere.

Telomerase.

Physical Description:

xii, 373 pages, 18 unnumbered pages of plates : illustrations (partly color) ; 24 cm.

Place of Publication:

[New York] : [Humana/]Springer, [2009]

Summary:

Telomeres and telomerase are the two pivotal players that determine the course of cellular sensecence and immortalization. A universal problem for all eukaryotic cells with linear chromosomes is telomere shortening due to "end-replication problems;" its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase-positive cells, and consequence of telomerase inhibition differ among species. Telomeres and Telomerase in Cancers, edited by Keiko Hiyama, focuses on human telomeres and telomerase, from their basic biology in normal human cells and cancer cells, to their clinical applications as diagnostic tools and therapeutic targets in anti-cancer strategies. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date research into the role of human telomeres and telomerase in cancer.

Contents:

Part I Basic Background

1 Telomeres and Telomerase in Humans / Keiko Hiyama, Eiso Hiyama, Jerry W. Shay 3

2 Telomere-Binding Proteins in Humans / Nadya Dimitrova 23

3 Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms / Amy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, Shawn E. Holt 47

4 Telomere Dysfunction and the DNA Damage Response / Malissa C. Diehl, Lynne W. Elmore, Shawn E. Holt 87

5 Alternative Lengthening of Telomeres in Human Cells / Hilda A. Pickett, Roger R. Reddel 127

6 Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer / Xin Huang, Zhenyu Ju 149

Part II Telomeres and Telomerase in Human Cancers

7 Role of Telomeres and Telomerase in Cancer / Keiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama 171

8 Diagnostic Value I: Solid Tumors / Eiso Hiyama, Keiko Hiyama 181

9 Diagnostic Value II: Hematopoietic Malignancies / Junko H. Ohyashiki, Kazuma Ohyashiki 211

10 Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors / Brittney-Shea Herbert, Erin M. Goldblatt 225

11 Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors / Chandanamali Punchihewa, Danzhou Yang 251

12 Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors / Hiroyuki Seimiya, Takashi Tsuruo 281

13 Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer / Toshiyoshi Fujiwara, Yasuo Urata, Noriaki Tanaka 293

Part III Experimental Protocols

14 Protocol I: Telomerase Activity and Telomerase Expression / Eiso Hiyama 315

15 Protocol II: Importance and Methods of Telomere G-Tail Length Quantification / Akira Shimamoto, Eriko Aoki, Angie M. Sera, Hidetoshi Tahara 337

16 Protocol III: Detection of Alternative Lengthening of Telomeres / Wei-Qin Jiang, Jeremy D. Henson, Axel A. Neumann, Roger R. Reddel 351.

Notes:

Includes bibliographical references and index.

ISBN:

9781603273060

1603273069

OCLC:

233933790