Renal cell carcinoma : molecular targets and clinical applications / Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.

Format:

Book

Contributor:

Bukowski, Ronald M.

Figlin, Robert A.

Motzer, Robert J.

Language:

English

Subjects (All):

Renal cell carcinoma.

Carcinoma, Renal Cell.

Kidney Neoplasms.

Medical Subjects:

Carcinoma, Renal Cell.

Kidney Neoplasms.

Physical Description:

xvii, 507 pages, 12 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Edition:

Second edition.

Place of Publication:

Totowa, N.J. : Humana Press, [2009]

Contents:

Targeted Therapy for Metastatic Renal Cell Carcinoma: Overview / Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer 1

Molecular Genetics in Inherited Renal Cell Carcinoma: Identification of Targets in the Hereditary Syndromes / Nadeem Dhanani, Cathy Vocke, Gennady Bratslavsky, W. Marston Linehan 13

Molecular Targets in Renal Tumors: Pathologic Assessment / Ming Zhou 35

Interferons and Interleukin-2: Molecular Basis of Activity and Therapeutic Results / Thomas E. Hutson, Snehal Thakkar, Peter Cohen, Ernest C. Borden 49

The Molecular Biology of Kidney Cancer and Its Clinical Translation into Treatment Strategies / William G. Kaelin Jr., Daniel J. George 79

VEGF: Biologic Aspects and Clinical Approaches / W. Kimryn Rathmell, Brian I. Rini 99

VEGF and PDGF Receptors: Biologic Relevance and Clinical Approaches to Inhibition / John S. Lam, Robert Figlin, Arie Belldegrun 119

Sunitinib and Axitinib in Renal Cell Carcinoma / Robert J. Motzer 151

Sorafenib in Renal Cell Carcinoma / Saby George, Ronald M. Bukowski 167

Additional Tyrosine Kinase Inhibitors in Renal Cell Carcinoma / Brian I. Rini 189

Integrin a5b1 as a Novel Therapeutic Target in Renal Cancer / Vanitha Ramakrishnan, Vinay Bhaskar, Melvin Fox, Keith Wilson, John C. Cheville, Barbara A. Finck 195

Carbonic Anhydrase IX: Biology and Clinical Approaches / Brian Shuch, Arie S. Belldegrun, Robert A. Figlin 211

Monoclonal Antibody G250 Recognizing Carbonic Anhydrase IX in Renal Cell Carcinoma: Biological and Clinical Studies / J. C. Oosterwijk-Wakka, Otto C. Boerman, Peter F. A. Mulders, Egbert Oosterwijk 231

Chemokines in Renal Cell Carcinoma: Implications for Tumor Angiogenesis and Metastasis / Karen L. Reckamp, Robert A. Figlin, Robert M. Strieter 249

PI3K/Akt/mTOR Pathway: A Growth and Proliferation Pathway / Daniel Cho, James W. Mier, Micheal B. Atkins 267

EGFR and HER2: Relevance in Renal Cell Carcinoma / Eric Jonasch, Cheryl Lyn Walker 287

Proteasome-NFkB Signaling Pathway: Relevance in RCC / Jorge A. Garcia, Susan A.J. Vaziri, Ram Ganapathi 305

The Role of Hepatocyte Growth Factor Pathway Signaling in Renal Cell Carcinoma / Benedetta Peruzzi, Jean-Baptiste Lattouf, Donald P. Bottaro 321

Smac/DIABLO: A Proapoptotic Molecular Target in Renal Cell Cancer / Yoichi Mizutani, Akihiro Kawauchi, Benjamin Bonavida, Tsuneharu Miki 335

EphA2: A Novel Target in Renal Cell Carcinoma / Mayumi Kawabe, Christopher J. Herrem, James H. Finke, Walter J. Storkus 347

Restoring Host Antitumoral Immunity: How Coregulatory Molecules Are Changing the Approach to the Management of Renal Cell Carcinoma / Brant A. Inman, Xavier Frigola, Haidong Dong, James C. Yang, Eugene D. Kwon 367

The Role of Gangliosides in Renal Cell Carcinoma / Philip E. Shaheen, Ronald M. Bukowski, James H. Finke 405

Tumour Necrosis Factor - Misnomer and Therapeutic Target / Marina Parton, Tanya Das, Gaurisankar Sa, James Finke, Tim Eisen, Charles Tannenbaum 425

Molecular Markers for Predicting Prognosis of Renal Cell Carcinoma / Mark Nogueira, Hyung L. Kim 449

Adjuvant Therapy for Renal Cell Carcinoma: Targeted Approaches / A. Karim Kadar, Christopher G. Wood 473.

Notes:

Includes bibliographical references and index.

ISBN:

9781588297372

1588297373

OCLC:

261948167