Gene family targeted molecular design / edited by Karen E. Lackey.

Format:

Book

Contributor:

Lackey, Karen.

Language:

English

Subjects (All):

Pharmacogenomics.

Drugs--Design.

Drugs.

Drug Design.

Genes.

Ion Channels--genetics.

Models, Molecular.

Pharmacogenetics--methods.

Medical Subjects:

Drug Design.

Genes.

Ion Channels--genetics.

Models, Molecular.

Pharmacogenetics--methods.

Physical Description:

xvi, 347 pages, 16 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Place of Publication:

Hoboken, N.J. : John Wiley & Sons, [2009]

Summary:

Gene Family Targeted Molecular Design enables scientists to design small molecules that target proteins and minimize interactions with other protein classes by focusing on major gene family targets. Bringing together and synthesizing the latest findings in the field, this book guides readers through compound design methods for generating small molecules that interact with important biological targets in G-protein coupled receptors /7-transmembrane receptors, ion channels, integrins, kinases, proteases, protein-protein interactions, transporters, and nuclear receptors. Each chapter covers all the critical issues to help readers design their own therapeutic small molecules, including:

Affinity for the intended target

Mechanism of the interaction

Examples of small molecules

Ways to change the molecule to attenuate activity

Pros and cons of different discovery methods

Gene Family Targeted Molecular Design begins with an introduction to drug discovery by gene family, which includes a list of suggested readings that provide more in-depth coverage of the functional areas of drug discovery that contribute to this stage of research. All chapters have been contributed by one or more leading researchers in small molecule design and include references to the primary literature. Many chapters feature case studies highlighting successful drug discovery efforts.

Synthetic, structural, computational, and medicinal chemists in academia, bio-medical companies, and the pharmaceutical industry will all benefit from this gene family focused approach to molecular design.

Contents:

Drug discoveries by gene family / Karen E. Lackey

G-protein-coupled receptors / Stephen L. Garland and Tom D. Heightman

Ion channels gene family: strategies for discovering ion channel drugs / Maria L. Garcia and Gregory J. Kaczorowski

Integrins / David D. Miller

Strategies for discovering kinase drugs / Jerry L. Adams ... [et al.]

Protease-directed drug discovery / Richard Sedrani, Ulrich Hommel, and Jor̈g Eder

Small-molecule inhibitors of protein-protein interactions: challenges and prospects / Adrian Whitty

Transporters / Anne Hersey, Frank E. Blaney, and Sandeep Modi

Nuclear receptor drug discovery / Hiroyuki Kagechika and Aya Tanatani

Summary and comparison of molecules designed to modulate druggable targets in the major gene families / Karen E. Lackey.

Notes:

Includes bibliographical references and index.

ISBN:

9780470412893

0470412895

OCLC:

233678601