The role of biofilms in device-related infections / Mark Shirtliff, Jeff G. Leid, editors.

Format:

Book

Contributor:

Shirtliff, Mark.

Leid, Jeff G.

Series:

Springer series on biofilms ; 3.

Springer series on biofilms ; v. 3

Language:

English

Subjects (All):

Prosthesis-Related Infections--etiology.

Bacterial Adhesion--physiology.

Biofilms.

Prostheses and Implants--adverse effects.

Prosthesis-Related Infections--physiopathology.

Pathogenic bacteria.

Bacterial diseases--Pathogenesis.

Bacterial diseases.

Host-parasite relationships.

Medical instruments and apparatus--Microbiology.

Medical instruments and apparatus.

Medical Subjects:

Prosthesis-Related Infections--etiology.

Bacterial Adhesion--physiology.

Biofilms.

Prostheses and Implants--adverse effects.

Prosthesis-Related Infections--physiopathology.

Physical Description:

xii, 269 pages : illustrations (some color) ; 25 cm.

Place of Publication:

Berlin : Springer, [2009]

Summary:

Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of ind-welling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 - 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.

Contents:

Microbial Ecology of Human Skin and Wounds / G. James, E. Swogger, E. deLancey-Pulcini 1

Infections of Orthopaedic Implants and Devices / Rebecca A. Brady, Jason H. Calhoun, Jeff G. Leid, Mark E. Shirtliff 15

Biofilms and Aseptic Loosening / Mark S. Smeltzer, Carl L. Nelson, Richard P. Evans 57

Biofilms and Ventilation / J. G. Thomas, L. Corum, K. Miller 75

Biofilm Formation on Natural Teeth and Dental Implants: What is the Difference? / Debora Armellini, Mark A. Reynolds, Janette M. Harro, Liene Molly 109

Complicated Urinary Tract Infections due to Catheters / G.A. O'May, S.M. Jacobsen, D.J. Stickler, H.L.T. Mobley, M.E. Shirtliff 123

Biofilms in Hemodialysis / Mark Pasmore, Karine Marion 167

Bacterial Endophthalmitis Following Cataract Surgery / M.E. Zegans, C.M. Toutain-Kidd, M.S. Gilmore 193

Use of Immunodiagnostics for the Early Detection of Biofilm Infections / Laura Selan, Jennifer Kofonow, Gian Luca Scoarughi, Tim Vail, Jeff G. Leid, Marco Artini 219

Immune Responses to Indwelling Medical Devices / M. Nymer, E. Cope, R. Brady, M.E. Shirtliff, J.G. Leid 239.

Notes:

Includes bibliographical references and index.

ISBN:

9783540681137

3540681132

9783540681199

3540681191

OCLC:

300399333