Epigenomics / Anne C. Ferguson-Smith, John M. Greally, Robert A. Martienssen, editors.

Format:

Book

Contributor:

Ferguson-Smith, Anne C.

Greally, John M.

Martienssen, Robert A.

Language:

English

Subjects (All):

Epigenesis.

Genomics.

Chromatin.

DNA.

Epigenesis, Genetic.

Medical Subjects:

Epigenesis, Genetic.

Chromatin.

Physical Description:

xiv, 438 pages : illustrations (some color) ; 25 cm

Place of Publication:

[Dordrecht?] : Springer, [2009]

Summary:

Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences, such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.

The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.

The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.

Contents:

Part I Epigenomic Technologies and Analytical Approaches

Strategies for Epigenome Analysis / A.B. Brinkman, H.G. Stunnenberg 3

Sequencing the Epigenome / Alexander Meissner, Bradley E. Bernstein 19

Integrating Epigenomic Results / Suk-Young Yoo, R.W. Doerge 37

Visualising the Epigenome / Paul Flicek, Ewan Birney 55

Part II Roles of DNA, RNA and Chromatin in Epigenomics

The Expanding View of Cytosine Methylation / J.M. Greally 69

Structural and Biochemical Advances in Mammalian DNA Methylation / Xiaodong Cheng, Robert M. Blumenthal 85

Epigenetic Profiling of Histone Variants / Steven Henkoff 101

Epigenetic Phenomena and Epigenomics in Maize / Jay B. Hollick, Nathan Springer 119

Epigenetic Silencing of Pericentromeric Heterochromatin by RNA Interference in Schizosaccharomyces pombe / Sarahjane Locke, Robert Martienssen 149

Describing Epigenomic Information in Arabidopsis / Ian R. Henderson 163

Role of Small RNA in Establishing Chromosomal Architecture in Drosophila / James A. Birchler 177

MacroRNAs in the Epigenetic Control of X-Chromosome Inactivation / Shinwa Shibata, Jeannie T. Lee 187

Part III Epigenetic Control of Developmental Processes

Polycomb Complexes and the Role of Epigenetic Memory in Development / Yuri B. Schwartz, Vincenzo Pirrotta 217

Genomic Imprinting - A Model for Roles of Histone Modifications in Epigenetic Control / Kirsten R. McEwen, Anne C. Ferguson-Smith 235

The Epigenomic Landscape of Reprogramming in Mammals / Gabriella Ficz, Cassandra R. Farthing, Wolf Reik 259

Epigenetic Gene Regulation-Lessons from Globin / Ann Dean, Steven Fiering 283

Meiotic Silencing, Infertility and X Chromosome Evolution / James M.A. Turner 301

Part IV The Epigenome in Health and Disease

Genome Defense: The Neurospora Paradigm / Michael R. Rountree, Eric U. Selker 321

Integrating the Genome and Epigenome in Human Disease / Claes Wadelius 343

A Changing Epigenome in Health and Disease / Esteban Ballestar, Manel Esteller 369

Cancer Epigenomics / Christine Ladd-Acosta, Andrew P. Feinberg 385

Epigenetic Modulation by Environmental Factors / Mark R. Doyle, Richard M. Amasino 397

The Relevance of Epigenetics of Major Psychosis / Jonathan Mill, Arturas Petronis 411.

Notes:

Includes bibliographical references and index.

ISBN:

9781402091865

1402091869

1402091877

9781402091872

OCLC:

260208389