Degradation rate of bioresorbable materials : prediction and evaluation / edited by Fraser Buchanan.

Format:

Book

Contributor:

Buchanan, Fraser.

Institute of Materials, Minerals, and Mining.

Alumni and Friends Memorial Book Fund.

Series:

Woodhead Publishing in materials

Language:

English

Subjects (All):

Absorbable Implants.

Biocompatible Materials.

Biodegradation, Environmental.

Biomedical materials--Biodegradation.

Biomedical materials.

Biodegradation.

Medical Subjects:

Absorbable Implants.

Biocompatible Materials.

Biodegradation, Environmental.

Physical Description:

xiii, 410 pages : illustrations ; 24 cm.

Place of Publication:

Cambridge, England : Woodhead Pub. and Maney Pub. on behalf of the Institute of Materials, Minerals & Mining ; Boca Raton : CRC Press, 2008.

Summary:

Bioresorbable materials are used extensively for a wide range of biomedical applications from drug delivery to fracture fixation, and may remain in the body for weeks, months or even years. Accurately predicting and evaluating the degradation rate of these materials is critical to their performance and the controlled release of bioactive agents. Degradation rate of bioresorbable materials: prediction and evaluation provides a comprehensive review of the most important techniques in safely predicting and evaluating the degradation rate of polymer, ceramic and composite based biomaterials.

Part I provides an introductory review of bioresorbable materials and the biological environment of the body. Chapters in Part II address degradation mechanisms of commonly used materials such as polymers and ceramics. This is followed by chapters on bioresorption test methods and modelling techniques in Part III. Part IV discusses factors influencing bioresorbability such as sterilisation, porosity and host response. The final section reviews current clinical applications of bioresorbable materials.

With its distinguished editor and multidisciplinary team of international contributors, Degradation rate of bioresorbable materials: prediction and evaluation will provide a unique and valuable reference for biomaterials scientists, engineers and students as well as the medical community.

Contents:

1 An overview of bioresorbable materials / K. J. L. Burg, D. E. Orr 3

1.2 Degradation mechanisms 4

1.3 Resorbable ceramics 5

1.4 Resorption process 6

1.5 Intended medical application guides the design of an absorbable implant 7

1.6 Understanding the in vivo environment 8

1.7 Naturally-derived materials 10

1.8 Synthesized polymers 11

1.9 Fabrication of absorbable materials 13

1.10 Sterilization of absorbable implants 16

1.12 Sources for further information and advice 17

2 The biological environment for bioresorbable materials / D. Lickorish, N. Zebardast, J. E. Davies 19

2.1 Introduction to a hostile environment 19

2.2 Blood 22

2.3 Plasma protein cascades 28

2.4 Fibrin information 31

2.5 Biomaterial interactions 33

2.6 Host response to injury 34

2.7 Practical demonstration of acute inflammation: The triple response 36

2.8 Chronic inflammation 37

2.9 Conclusion and future trends 37

Part II Degradation mechanisms 41

3 Synthetic bioresorbable polymers / R. E. Cameron, A. Kamvari-Moghaddam 43

3.2 Bioresorbable polymers 44

3.3 Degradation of aliphatic polyesters 48

3.4 Factors affecting aliphatic polymer degradation 54

3.5 Processing and devices 60

3.7 Sources of further information and advice 61

4 Natural bioresorbable polymers / W. Paul, C. P. Sharma 67

4.2 Chitin and chitosan 68

4.3 Alginates 75

4.4 Cellulose 83

5 Bioresorbable ceramics / M. Bohner 95

5.2 Solubility 99

5.3 Kinetics 101

5.4 In vivo transformation 102

5.5 Other bioresorbable ceramics 104

5.6 Modelling resorption 107

5.7 Future trends 108

Part III Bioresorption test methods 115

6 In vitro physicochemical test methods to evaluate bioresorbability / S. Li 117

6.2 Protocol for in vitro degradation studies 120

6.3 In vitro physicochemical test methods 121

7 In vitro biological test methods to evaluate bioresorbability / G. Mabilleau, A. Sabokbar 145

7.2 Methods of degradation of biomaterials 146

7.3 Methods of assessing resorbability in vitro 152

7.4 Characterization of the resorbability in vitro: Microscopic analysis of the surface 154

8 In vivo test methods to evaluate bioresorbability / S. A. Clarke, G. R. Jordan 161

8.2 In vivo models 162

8.3 Outcome measures 170

8.4 Histomorphometric measurements 172

8.5 Imaging 175

9 Modelling of the degradation processes for bioresorbable polymers / D. Farrar 183

9.2 Overview of degradation processes for bioresorbable polymers 184

9.3 Modelling of key processes 186

9.4 Modelling of surface erosion 199

9.5 Temperature effects 201

9.6 Future trends 202

Part IV Factors influencing bioresorption 207

10 Influence of processing, sterilisation and storage on bioresorbability / F. Buchanan, D. Leonard 209

10.2 Processing techniques 210

10.3 Processing-related degradation 212

10.4 Sterilisation 220

10.5 Maximising shelf-life: Packaging and storage 226

10.6 Additives for reducing degradation 229

11 Influence of porous structure on bioresorbability: Tissue engineering scaffolds / P. Tomlins 234

11.2 Materials 235

11.3 Processing 238

11.4 Characterisation of tissue scaffolds 244

11.5 Methods for monitoring the degradation of polymeric tissue scaffolds 247

Part V Clinical application 265

12 Influence of clinical application on bioresorbability: Host response / J. C. Y. Chan, K. Burugapalli, J. L. Kelly, A. S. Pandit 267

12.2 Host response cascade 268

12.3 Host factors influencing biodegradation 271

12.4 Influence of site of implantation on biodegradation 283

12.5 Influence of species and repeated implantation 285

12.6 Adverse outcomes of biodegradable polymers 285

12.7 Mechanisms of in vivo biodegradation 286

12.8 Material factors influencing biodegradation 290

12.9 Biomaterial design parameters 298

13 Scaffold and implant design: Considerations relating to characterization of biodegradability and bioresorbability / D. W. Hutmacher, C. X. F. Lam 319

13.2 Biodegradation and bioresorption 320

13.3 Hydrolytic degradation of polycaprolactone 323

13.4 Hydrolytic degradation of medical polycaprolactone (mPCL) versus research polycaprolactone (PCL) 325

13.5 In vivo degradation of polycaprolactone-based scaffolds 343

14 Drug release from bioresorbable materials / M. Westwood, D. S. Jones 357

14.2 Examples of biodegradable pharmaceutical polymers 359

14.3 Mechanisms of drug release from biodegradable polymers 373

14.4 Drug delivery applications of biodegradable polymers 377.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

9781845693299

1845693299

9781420079715

1420079719

9781845695033

1845695038

OCLC:

243740453