Safety of nanoparticles : from manufacturing to medical applications / Thomas J. Webster, editor.

Format:

Book

Contributor:

Webster, Thomas J., 1971-

Language:

English

Subjects (All):

Nanostructured materials--Safety measures.

Nanostructured materials.

Biomedical engineering--Safety measures.

Biomedical engineering.

Industrial safety.

Physical Description:

xii, 239 pages : illustrations ; 24 cm

Place of Publication:

New York : Springer, [2009]

Summary:

In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected. The aim of this book is to provide one of the first detailed overviews of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.

Contents:

1 Developing Practices for Safe Handling of Nanoparticles and Nanomaterials in a Development-Stage Enterprise: A Practical Guide for Research and Development Organizations / Robert A. Hoerr, Anand Gupta, Michael J. Matuszewski 1

2 Cytotoxicity of Photoactive Naoparticles / Yuhui Jin, Xiaojun Zhao 19

3 Breeching Epithelial Barriers-Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity / Lisa DeLouise, Luke Mortensen, Alison Elder 33

4 Safety and Efficacy of Nano/Micro Materials / Xiaohong Wei, Yong-kyu Lee, Kang Moo Huh, Sungwon Kim, Kinam Park 63

5 Biomedical Applications of Nanoparticles / G.L. Prasad 89

6 Unexpected Reactions by In Vivo Applications of PEGylated Liposomes / Tatsuhiro Ishida, Hiroshi Kiwada 111

7 Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility, and Toxicity Analysis / Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt 131

8 Cytotoxicity and Genotoxicity of Carbon Nanomaterials / Amanda M. Schrand, Jay Johnson, Liming Dai, Saber M. Hussain, John J. Schlager, Lin Zhu, Yiling Hong, Eiji Osawa 159

9 Calcium Phosphate Nanoparticles: Toxicology and Lymph Node Targeting for Cancer Metastasis Prevention / Rajesh A. Pareta 189

10 Nanoparticles for Cancer Diagnosis and Therapy / Andrew Z. Wang, Frank X. Gu, Omid C. Farokhzad 209.

ISBN:

9780387786070

0387786074

OCLC:

233935183