Intracellular traffic and neurodegenerative disorders / Peter H. St. George-Hyslop, William C. Mobley, Yves Christen, editors.

Format:

Book

Contributor:

St. George-Hyslop, Peter.

Mobley, William C.

Christen, Yves.

Series:

Research and perspectives in Alzheimer's disease

Language:

English

Subjects (All):

Nervous system--Degeneration--Pathophysiology.

Nervous system.

Proteins--Physiological transport.

Proteins.

Cellular signal transduction.

Neurodegenerative Diseases--physiopathology.

Protein Transport.

Signal Transduction.

Nervous system--Degeneration.

Medical Subjects:

Neurodegenerative Diseases--physiopathology.

Protein Transport.

Signal Transduction.

Physical Description:

xiv, 183 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Berlin ; London : Springer, [2009]

Summary:

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

Contents:

Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms / Sam Gandy, Odete da Cruz e Silva, Edgar da Cruz e Silva, Toshiharu Suzuki, Michelle Ehrlich, Scott Small 1

Intramembrane Proteolysis by [gamma]-Secretase and Signal Peptide Peptidases / Regina Fluhrer, Christian Haass 11

Axonal Transport and Neurodegenerative Disease / Erika L. F. Holzbaur 27

Simple Cellular Solutions to Complex Problems / Susan Lindquist, Karen L. Allendoerfer 41

Tau and Intracellular Transport in Neurons / E.-M. Mandelkow, E. Thies, S. Konzack, E. Mandelkow 59

Signaling Between Synapse and Nucleus During Synaptic Plasticity / Kwok-On Lai, Dan Wang, Kelsey C. Martin 71

Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration? / Ahmad Salehi, Chengbiao Wu, Ke Zhan, William C. Mobley 87

Membrane Trafficking and Targeting in Alzheimer's Disease / Lawrence Rajendran, Kai Simons 103

Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport / Frederic Saudou, Sandrine Humbert 115

The Role of Retromer in Neurodegenerative Disease / Claire F. Skinner, Matthew N.J. Seaman 125

Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease / Alexander Sorkin 141

The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease / Ekaterina Rogaeva, Yan Meng, Joseph H. Lee, Richard Mayeux, Lindsay A. Farrer, Peter St George-Hyslop 157

Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA / Thomas E. Willnow, Michael Rohe, Vanessa Schmidt 167.

Notes:

On cover: Fondation Ipsen pour la recherche therapeutique.

Includes bibliographical references and index.

ISBN:

9783540879404

3540879404

OCLC:

261955196