Mitochondria and cancer / edited by Keshav Singh, Leslie Costello.

Format:

Book

Contributor:

Singh, Keshav K.

Costello, Leslie.

Language:

English

Subjects (All):

Cancer--Genetic aspects.

Cancer.

Mitochondria.

Mitochondrial pathology.

Neoplasms--genetics.

Mitochondria--pathology.

Medical Subjects:

Neoplasms--genetics.

Mitochondria--pathology.

Physical Description:

xii, 289 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Place of Publication:

New York ; London : Springer, [2009]

Summary:

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity; in molecular composition of mitochondria and mtDNA sequence; and in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer and discusses the clinical implications of mitochondrial defects in cancer. It also discusses the practicality of using these defects as unique cellular targets for novel and selective anti-cancer therapy.

Contents:

Mitochondria and Cancer / Kjerstin M. Owens, J.S. Modica-Napolitano, Keshav K. Singh 1

Warburg and his Legacy / Michael Ristow, Tim J. Schulz 23

The Lipogenic Switch in Cancer / Koen Brusselmans, Johannes V. Swinnen 39

Citrate Metabolism in Prostate and Other Cancers / Renty B. Franklin, Leslie C. Costello 61

Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism / Leslie C. Costello, Renty B. Franklin 79

Mitochondrial Respiration and Differentiation / Roberto Scatena, Patrizia Bottoni, Bruno Giardina 93

Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells / John G. Pastorino, Jan B. Hoek 103

Energy Generating Pathways and the Tumor Suppressor p53 / Chad A. Corcoran, Ying Huang, M. Saeed Sheikh 131

Mitochondrial Tumor Suppressors / Bora E. Baysal 151

Mitochondria in Hematology / Stefanie Zanssen 163

Mitochondria and Oncocytomas / J. Lima, V. Maximo, P. Soares, R. Portugal, S. Guimaraes, M. Sobrinho-Simoes 193

Mitochondria as Targets for Cancer Therapy / Stephen J. Ralph, Jiri Neuzil 211

Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy / Gopinath Sutendra, Evangelos D. Michelakis 251

Mitochondrial Nanotechnology for Cancer Therapy / Volkmar Weissig, Gerard G.M. D'Souza, Shing-Ming Cheng, Sarathi Boddapati 265.

Notes:

Includes bibliographical references and index.

ISBN:

9780387848341

0387848347

OCLC:

245561344