Targeted radionuclide tumor therapy : biological aspects / Torgny Stigbrand, Jörgen Carlsson, Gregory P. Adams, editors.

Format:

Book

Contributor:

Stigbrand, Torgny.

Carlsson, Jörgen, 1960-

Adams, Gregory P.

Language:

English

Subjects (All):

Tumors--Radionuclide imaging.

Tumors.

Tumors--Treatment.

Nuclear medicine.

Neoplasms--therapy.

Radioisotopes--therapeutic use.

Antibodies--therapeutic use.

Radioisotope scanning.

Medical Subjects:

Neoplasms--therapy.

Radioisotopes--therapeutic use.

Antibodies--therapeutic use.

Physical Description:

xiii, 402 pages : illustrations (some color), color portraits ; 24 cm

Place of Publication:

[New York?] : Springer, [2008]

Summary:

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book Targeted Radionuclide Tumor Therapy - Biological Aspects was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future. The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. it also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.

It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.

Contents:

1 Introduction to Radionuclide Therapy / Jorgen Carlsson, Torgny Stigbrand, Gregory P. Adams 1

2 Therapeutically Used Targeted Antigens in Radioimmunotherapy / Torgny Stigbrand, David Eriksson, Katrine Riklund, Lennart Johansson 13

3 EGFR-Family Expression and Implications for Targeted Radionuclide Therapy / Jorgen Carlsson 25

4 Targeting Tumours with Radiolabeled Antibodies / Torgny Stigbrand, David Eriksson, Katrine Riklund, Lennart Johansson 59

5 Antibody Fragments Produced by Recombinant and Proteolytic Methods / Gregory P. Adams 77

6 Novel Alternative Scaffolds and Their Potential Use for Tumor Targeted Radionuclide Therapy / Fredrik Y. Frejd 89

7 Peptides for Radionuclide Therapy / Marion de Jong, Suzanne M. Verwijnen, Monique de Visser, Dik J. Kwekkeboom, Roelf Valkema, Eric P. Krenning 117

8 Choice of Radionuclides and Radiolabelling Techniques / Vladimir Tolmachev 145

9 High-LET-Emitting Radionuclides for Cancer Therapy / George Sgouros 175

10 Targeted High-LET Therapy of Bone Metastases / Oyvind S. Bruland, Dahle Jostein, Dag Rune Olsen, Roy H. Larsen 181

11 The Auger Effect in Molecular Targeting Therapy / Hans Lundqvist, Bo Stenerlow, Lars Gedda 195

12 Radiation Induced Cell Deaths / David Eriksson, Katrine Riklund, Lennart Johansson, Torgny Stigbrand 215

13 Radiation Induced DNA-Damage/Repair and Associated Signaling Pathways / Bo Stenerlow, Lina Ekerljung, Jorgen Carlsson, Johan Lennartsson 249

14 Radiation Induced DNA Damage Checkpoints / David Eriksson, Katrine Riklund, Lennart Johansson, Torgny Stigbrand 267

15 Cancer Stem Cells and Radiation / David Eriksson, Katrine Riklund, Lennart Johansson, Torgny Stigbrand 285

16 Effects of Low Dose-Rate Radiation on Cellular Survival / Jorgen Carlsson 295

17 Bystander Effects and Radionuclide Therapy / Kevin M. Prise 311

18 Enhancing the Efficiency of Targeted Radionuclide Therapy / Gregory P. Adams 321

19 Low Dose Hyper-Radiosensitivity: A Historical Perspective / Brian Marples, Sarah A. Krueger, Spencer J. Collis, Michael C. Joiner 329

20 Clinical Radionuclide Therapy / Andrew M. Scott, Sze-Ting Lee 349

21 Developmental Trends in Targeted Radionuclide Therapy: Biological Aspects / Torgny Stigbrand, Jorgen Carlsson, Gregory P. Adams 387.

Notes:

Includes bibliographical references and index.

ISBN:

9781402086953

1402086954

OCLC:

233933805