Thrombin : physiology and disease / Michael E. Maragoudakis, Nikos E. Tsopanoglou, editors.

Format:

Book

Contributor:

Maragoudakis, Michael E.

Tsopanoglou, Nikos E.

Language:

English

Subjects (All):

Thrombin.

Thrombin--Physiological effect.

Blood--Coagulation.

Blood.

Thrombolytic therapy.

Thrombin--physiology.

Blood Coagulation.

Thrombolytic Therapy.

Medical Subjects:

Thrombin--physiology.

Blood Coagulation.

Thrombolytic Therapy.

Physical Description:

xii, 266 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Place of Publication:

New York : Springer, [2009]

Summary:

It has become increasingly evident in recent years that apart from the key role of thrombin in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are implicated in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, and angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets.

Contents:

1 Thrombin: Structure, Functions, and Regulation / Enrico Di Cera, Andras Gruber 1

2 Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation / Rithwik Ramachandran, Mahmoud El-Daly, Mahmoud Saifeddine, Morley D. Hollenberg 19

3 Regulation of Thrombin Receptor Signaling / JoAnn Trejo 47

4 Thrombin and Activated Protein C: Integrated to Regulate Vascular Physiology / Matthias Riewald 63

5 The Role of Thrombin in Vascular Development / Martin Moser, Cam Patterson 81

6 The Role of Thrombin in Angiogenesis / Nikos E. Tsopanoglou, Michael E. Maragoudakis 93

7 Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair / Barbara Olszewska-Pazdrak, John S. Bergmann, Gerald M. Fuller, Darrell H. Carney 115

8 The Role of Thrombin and Thrombin Receptors in the Brain / Weibo Luo, Yingfei Wang, Georg Reiser 133

9 The Role of Thrombin in Tumor Biology / Boris Kobrinsky, Simon Karpatkin 161

10 The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation / Zaidoun Salah, Sorina Grisaru-Granovsky, Myriam Maoz, Beatrice Uziely, Irit Cohen, Hagit Turm, Tamar Peretz, Rachel Bar-Shavit 173

11 Anti-thrombotic Therapy in Cancer Patients / Gloria A. Petralia, Ajay K. Kakkar 189

12 Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application / Cailin Chen, Bruce E. Maryanoff, Patricia Andrade-Gordon 205

13 Novel Anticoagulant Therapy: Principle and Practice / Shaker A. Mousa 237.

Notes:

Includes bibliographical references and index.

ISBN:

9780387096360

0387096361

OCLC:

233789103