Successful randomized trials : a handbook for the 21st century / edited by Michael J. Domanski, Sonja McKinlay.

Format:

Book

Contributor:

Domanski, Michael J.

McKinlay, Sonja.

Language:

English

Subjects (All):

Clinical trials.

Randomized Controlled Trials as Topic.

Medical Subjects:

Randomized Controlled Trials as Topic.

Physical Description:

xvi, 199 pages : illustrations ; 22 cm

Place of Publication:

Philadelphia : Wolters Kluwer Health/Lippincott Williams & Wilkins, [2009]

Summary:

This handbook is an easy-to-read reference on the theory and operation of modern large, multi-center randomized clinical trials intended for clinicians, clinical investigators, and students of medicine and public health. Written in a concise, engaging style, this comprehensive text includes practical considerations in the design and implementation of multi-center studies seldom found in standard texts on the subject.

Highlights of this handbook: Concise, easy-to-read reference that covers all the key issues for clinical researchers and statisticians who are not acquainted with randomized clinical trials, Numerous examples, illustrations and helpful checklists List of selected further reading at the end of each chapter Contributions by globally recognized authorities on clinical trials And more. This book is an essential reference for anyone learning about or implementing clinical trials.

Contents:

Randomized clinical trials / Michael J. Domanski and Sonja McKinlay

Designing clinical trials / Susan F. Assmann

Randomization: what it is and how to do it / Catherine E. Hewitt and David J. Torgerson

Setting sample size for randomized clinical trials / Xin Tian, Sonja M. McKinlay, and Nancy L. Geller

Analytic approach and methods / Lynn A. Sleeper

Ethical considerations / Lawrence M. Friedman and Eleanor B. Schron

Study organization and governance / Fleur Hudson, Julie Bakobaki, and Abdel Babiker

Quality control and quality assurance / Flora S. Siami

Quality assurance: prevention of missing data / James Neaton

Surrogate endpoints / Robert Fiorentino

Registries / Hesha Duggirala

Gazing into the crystal ball: the future of randomized clinical trials / Michael J. Domanski, Sonja M. McKinlay, and Marc Pfeffer.

Notes:

Includes bibliographical references and index.

ISBN:

9780781779456

0781779456

OCLC:

237195058

Online:

Publisher description