Molecular neuropharmacology : a foundation for clinical neuroscience / Eric J. Nestler, Steven E. Hyman, Robert C. Malenka.

Format:

Book

Author/Creator:

Nestler, Eric J. (Eric Jonathan), 1954-

Contributor:

Hyman, Steven E.

Malenka, Robert C.

Class of 1932 Fund.

Language:

English

Subjects (All):

Neuropharmacology.

Molecular neurobiology.

Central Nervous System Agents--pharmacology.

Central Nervous System--drug effects.

Central Nervous System--physiology.

Central Nervous System Diseases--drug therapy.

Medical Subjects:

Central Nervous System Agents--pharmacology.

Central Nervous System--drug effects.

Central Nervous System--physiology.

Central Nervous System Diseases--drug therapy.

Physical Description:

xiv, 498 pages : illustrations (chiefly color) ; 26 cm

Edition:

Second edition.

Place of Publication:

New York : McGraw-Hill Medical, [2009]

Summary:

Molecular Neuropharmacology offers a clear, thorough explanation of the molecular functioning of the nervous system in normal and disease states. More than three hundred full-color illustrations along with didactic text boxes provide an in-depth understanding of nerve cell receptors, their effectors and second messenger targets, and the molecular genetics that are often impacted by these systems. You will also learn how malfunction of these molecular systems relates to human disease and the corresponding medical treatment. Molecular Neuropharmacology is the most relevant, well-written resource available to help you make the connection between neuropharmacology and clinical neuroscience.

Contents:

Part 1 Fundamentals of Neuropharmacology

1 Basic Principles of Neuropharmacology 3

2 Cellular Basis of Communication 16

3 Synaptic Transmission 55

4 Signal Transduction in the Brain 74

Part 2 Neural Substrates of Drug Action

5 Excitatory and Inhibitory Amino Acids 117

6 Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin 145

7 Neuropeptides 181

8 Atypical Neurotransmitters 199

Part 3 Neuropharmacology of Neural Systems and Disorders

9 Autonomic Nervous System 227

10 Neural and Neuroendocrine Control of the Internal Milieu 246

11 Pain and Inflammation 269

12 Sleep and Arousal 289

13 Higher Cognitive Function and Behavioral Control 313

14 Mood and Emotion 335

15 Reinforcement and Addictive Disorders 364

16 Schizophrenia and Other Psychoses 389

17 Neurodegeneration 409

18 Seizure Disorders 443

19 Stroke and Migraine 457.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Class of 1932 Fund.

ISBN:

9780071481274

0071481273

OCLC:

184828210