Gene therapy immunology / edited by Roland Herzog.

Format:

Book

Contributor:

Herzog, Roland W., 1970-

Language:

English

Subjects (All):

Gene therapy.

Immunology.

Genetic Therapy.

Gene Transfer Techniques.

Immune Tolerance.

Immunity, Innate.

Transplantation Immunology.

Medical Subjects:

Genetic Therapy.

Gene Transfer Techniques.

Immune Tolerance.

Immunity, Innate.

Transplantation Immunology.

Physical Description:

xii, 397 pages : illustrations ; 25 cm

Place of Publication:

Hoboken, N.J. : Wiley-Blackwell, [2009]

Summary:

Gene Therapy Immunology is the first book of its kind to summarize and present a broad review of the latest immunological advances in the field of genetic therapy. The book's unique organization, which approaches the topic from a vector and target organ point of view, rather than from a disease-specific perspective, reflects the ways in which gene therapies are being investigated today. This provides scientists and physicians attempting to develop gene therapies with a powerful tool for comparing vectors and target organs side by side, making the right investigative and clinical choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues.

Each chapter covers local and systemic responses; strengths and characteristics of innate responses; strengths and characteristics of adaptive (i.e., T helper, cytotoxic T lymphocyte, and B cell/antibody) responses to the vector and to transgene products; and preexisting immunity in humans.

Authored by internationally renowned researchers and clinicians and edited by the former chair of the Immunology Committee of the American Society for Gene Therapy, this book is an indispensable resource for scientists, physicians, and students who work in gene therapy. It is also a valuable text for advanced undergraduate and graduate courses on immunology.

Contents:

The immunology of gene transfer: an overview / Braden Waters and David Lillicrap

Innate immune responses to nucleic acids / Ken J. Ishii, Shohei Koyama, and Shizuo Akira

The antiviral innate immune response / Mark E. Seamone and Daniel A. Muruve

Immune responses to adenoviral vectors / Nelson C. DiPaolo and Dmitry M. Shayakhmetov

Immune responses to lentiviral vectors / Lung-Ji Chang

Immune responses to adeno-associated virus vectors / Shih-Wen Lin and Hildegund Ertl

Immune responses after in utero and neonatal gene transfer / Simon N. Waddington ... [et al.]

Immunology of hepatic gene transfer / Brad E. Hoffman and Roland W. Herzog

Immune responses to adenoviral, adeno-associated viral, and lentiviral vectors used for gene therapy of brain diseases / Pedro R. Lowenstein ... [et al.]

Immunology of cutaneous gene transfer / Soosan Ghazizadeh

Immune responses to pulmonary gene therapy / Christian Müller and Terence R. Flotte

Induction of immune tolerance through gene transfer to hematopoietic stem cells / Jessamyn Bagley, Chaorui Tian and John Iacomini

Reconstitution of the immune system by gene therapy / Waseem Qasim and Adrian Thrasher

Genetics of the immune response to proteins expressed after gene transfer / Jay Lozier

Immune modulation and transient suppression strategies / Valder R. Arruda

Gene therapy for autoimmune diseases / Massimo M. Trucco, Paul D. Robbins, and Nick Giannoukakis

Engineering of viral capsids to evade the host immune system / Luca Perabo ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0470134062

9780470134061

OCLC:

253188920