Pharmacogenomics and personalized medicine / Nadine Cohen, editor.

Format:

Book

Contributor:

Cohen, Nadine.

Series:

Methods in pharmacology and toxicology

Language:

English

Subjects (All):

Pharmacogenomics.

Drug development.

Pharmacogenetics.

Drug Design.

Medical Subjects:

Pharmacogenetics.

Drug Design.

Physical Description:

xv, 509 pages : illustrations ; 25 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2008]

Summary:

With the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease, and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community, and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities, and obstacles in its application. Focusing on DNA data and associated analytical methodologies, this volume includes a wide array of vital, cutting-edge research.

Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.

Contents:

Challenges, opportunities, and evolving landscapes in pharmacogenomics and personalized medicine: an industry perspective / Nadine Cohen and Theresa Frangiosa

Implementation of pharmacogenomic sample collection in clinical trials / Deborah Sokol Ricci and Monique Franc

Pharmacogenomics: the regulatory environment and labeling implications / Myong-Jin Kim ... [et al.]

Applications of pharmacogenomics in drug discovery / Duncan McHale

Applications of pharmacogenomics in clinical trials / Monique Franc

Pharmacogenomics applications in drug metabolism: from genotyping to drug label-challenges? / Ann K. Daly

The genetics of adverse drug reactions: promises and problems / Martin Armstrong

Strategies and resources for marker selection and genotyping in genetic association studies / Nicole Soranzo, Dong-Jing Fu, and Qingqin S. Li

Study design and statistical issues in pharmacogenetics research: from candidate genes to genome-wide screens / Nicholas J. Schork, Nathalie Malo, and Eric J. Topol

Holy SNP, Batman! / Reyna Favis

Predictive biomarker classifiers in the design of pivotal clinical trials / Richard Simon

Translation of biomarkers into clinical utility / William L. Trepicchio and George Mulligan

Pharmacogenomic study feasibility assessment and pharmaceutical business decision-making / Monique Franc and Theresa Frangiosa

Co-development of drugs and pharmacogenomics-based diagnostics in oncology / Jeffrey S. Ross

Pharmacogenomics applications in epilepsy / Chantal Depondt

Pharmacogenomics in Alzheimer's disease / Ramón Cacabelos

Pharmacogenomics applications in psychiatric disorders / Todd Lencz and Anil K. Malhotra

Pharmacogenomics in HIV disease / Amalio Telenti

Pharmacogenomics and cardiovascular drugs / Gérard Siest ... [et al.]

Pharmacogenomic applications in children / Susan F.A. Grant and Hakon Hakonarson

Pharmacogenomics of rare and monogenic disorders / Paul D. Maher.

Notes:

Includes bibliographical references and index.

ISBN:

9781934115046

1934115045

OCLC:

213114046