Cancer epigenetics / edited by Trygve Tollefsbol.

Format:

Book

Contributor:

Tollefsbol, Trygve O.

Language:

English

Subjects (All):

Cancer--Genetic aspects.

Cancer.

Epigenesis.

DNA--Methylation.

DNA.

Post-translational modification.

Neoplasms--genetics.

DNA Methylation.

Epigenesis, Genetic.

Histones--metabolism.

Medical Subjects:

Neoplasms--genetics.

DNA Methylation.

Epigenesis, Genetic.

Histones--metabolism.

Physical Description:

xvi, 446 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

Boca Raton : CRC Press, [2009]

Summary:

Elucidating the most-recent advances in the genomic breakthrough of epigenetics, this cutting-edge work covers a wide array of aspects ranging from the role of epigenetics in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy.

Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy.

With stand-alone chapters authored by research pioneers in the field, this definitive resource-: Discusses the recent advances in the role of epigenetics in tumor initiation, progression, and metastasis, Describes the importance of dietary and environmental factors on cancer epigenetics, Ranges from basic science to landmark discoveries in clinical practice, Highlights diagnostic and prognostic aspects of epigenetics in cancer and advances in gene therapy, Covers emerging aspects, such as RNA epigenetics, chromosomal position effects, epigenomics, and the role of polycomb-group genes in cancer.

Cancer Epigenetics is an indispensable reference for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. Serving as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer, this seminal work answers the call for a thorough and authoritative book that covers the critical and contemporary aspects of this revolutionary field.

Contents:

The role of epigenetics in cancer / Trygve O. Tollefsbol

DNA hypomethylation in cancer / Peter L. Molloy

DNA hypermethylation in oncogenesis / J. Tyson DeAngelis ... [et al.]

Imprinting alterations in tumorigenesis / Jeremiah Bernier-Latmani and Phillip Shaw

Proteins that modulate DNA methylation aberrations in cancer / Sabrina L. Walthall ... [et al.]

Role of DNA methylation in cancer progression / Sang-Woon Choi and Simonetta Friso

Alterations in histone acetylation in tumorigenesis / Sabita N. Saldanha and Trygve O. Tollefsbol

Histone methylation and the initiation of cancer / Shi Huang

The role of sirtuins in aging and tumorigenesis / Xiaohong Zhang ... [et al.]

Proteins that alter histone modifications in cancer / Ada Ao and Jianrong Lu

Dietary and environmental influences on histone modifications in cancer / Sabita N. Saldanha ... [et al.]

Noncoding RNAs in cancer / Maciej Szymański and Jan Barciszewski

Cancer-linked DNA hypermethylation and hypomethylation: chromosome position effects / Melanie Ehrlich

Chromatin remodeling and cancer / Sari Pennings and Richard R. Meehan

Poly-ADP-ribosylation in cancer / Rajeshwar Nath Sharan

Polycomb group proteins in tumorigenesis / Hanneke E.C. Niessen and Jan Willem Voncken

Cancer and aging: the epigenetic connection / Craig A. Cooney

DNA methylation in tumor diagnosis / Kavitha Ramachandran, Edna Gordian, and Rakesh Singal

DNA methylation profiles as prognostic markers for cancer / Sam Thiagalingam and Panagiotis Papageorgis

Diagnosing cancer using histone modification analysis / Mukesh Verma and Deepak Kumar

Histone modifications in cancer biology and prognosis / Matthew A. McBrian, David B. Seligson, and Siavash K. Kurdistani

Histone deacetylase inhibitors in cancer therapy / Aaron M. Sargeant ... [et al.]

Methylation changes in neoplasia: diagnostic and therapeutic implications / Eleftheria Hatzimichael, Justin Stebbing, and Tim Crook

Clinical trials and approved drugs for epigenetic cancer therapy / Debby M.E.I. Hellebrekers and Manon van Engeland

Future directions in epigenetic cancer research / Jacob Peedicayil.

Notes:

Includes bibliographical references and index.

ISBN:

9781420045796

1420045792

OCLC:

214299970

Online:

Publisher description