Signal transduction in the cardiovascular system in health and disease / Ashok K. Srivastava, Madhu B. Anand-Srivastava, editors.

Format:

Book

Contributor:

Srivastava, Ashok K.

Anand-Srivastava, Madhu B.

Series:

Advances in biochemistry in health and disease ; v. 3.

Advances in biochemistry in health and disease ; v. 3

Language:

English

Subjects (All):

Cardiovascular system--Diseases--Molecular aspects.

Cardiovascular system.

Cellular signal transduction.

Cardiovascular Diseases--microbiology.

Signal Transduction.

Cardiovascular system--Diseases.

Medical Subjects:

Cardiovascular Diseases--microbiology.

Signal Transduction.

Physical Description:

xviii, 424 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 24 cm.

Place of Publication:

New York : Springer, [2008]

Summary:

This book has addressed the contributions of several key signal transduction pathways which are central to our understanding of cardiovascular physiology and pathophysiology. Aberrations in these signaling events have been suggested to be involved in a host of cardiovascular pathologies, such as cardiac arrhythmias, congenital heart failure and hypertension.

All the chapters have been written by well known leaders in the fields, which cover a wide range of intracellular events that regulate various aspects of cardiovascular functions. This book will be of interest to both basic as well as clinical scientists seeking to understand the molecular basis of cardiovascular diseases, and also to those interested in defining targets for cardiovascular pharmacotherapy.

Contents:

Part I G-protein-Coupled Receptor Signaling

1 Implication of G-proteins in Cardiovascular Disease / Madhu B. Anand-Srivastava 3

2 [beta]-Adrenoceptor-Linked Signal Transduction Mechanisms in Congestive Heart Failure / Melissa R. Dent, Tushi Singal, Paramjit S. Tappia, Rajat Sethi, Naranjan S. Dhalla 27

3 Cardiac G[alpha]s and G[alpha]i Modulate Sympathetic Versus Parasympathetic Mechanisms in Hyperhomocysteinemia / Thomas P. Vacek, Karni S. Moshal, Naira Metreveli, Neetu Tyagi, Utpal Sen, Dorothea Rosenberger, Suresh C. Tyagi 51

4 The Role of the Beta-Adrenergic Signal Transduction Pathway in Myocardial Protection / John Moolman, Erna Marais, Sonia Genade, Syanda Makaula, Amanda Lochner 67

5 Angiotensin II Signaling in Vascular Physiology and Pathophysiology / Niels Engberding, Kathy K. Griendling 89

6 Angiotensin II Signaling: Cell Growth and Apoptosis / Stephen W. Schaffer, Mahmood S. Mozaffari 117

Part II Redox Signaling

7 Thioredoxin Signaling in the Ischemic Heart / Dipak K. Das, Shyamal K. Goswami 141

8 Relationship Between Redox Regulation and [beta]-Adrenergic Responses in the Heart / Belma Turan 157

9 Role of Hyperglycemia and Redox-Induced Signaling in Vascular Complications of Diabetes / Ashok K. Srivastava, Madhu B. Anand-Srivastava 177

10 Methylglyoxal and Insulin Resistance / Lingyun Wu 193

Part III Growth Factor Signaling

11 Role of Growth Factor Receptor Transactivation in Vasoactive Peptide-Induced Signaling Pathways in Vascular Smooth Muscle Cells / Ali Bouallegue, Ashok K. Srivastava 211

12 Identifying the Cellular and Molecular Events Associated with the Divergent Phenotypes of Cardiac Hypertrophy / Angelino Calderone 229

13 Regulatory Role of TGF-[beta] in Cardiac Myofibroblast Function and Post-MI Cardiac Fibrosis: Key Roles of Smad7 and c-Ski / Ian M.C. Dixon, Baiqiu Wang, Kristen M. Bedosky, Ryan H. Cunnington, Sunil G. Rattan, Ahmed Almaqrhi 249

14 The Signaling Duel Between Virus and Host: Impact on Coxsackieviral Pathogenesis / Xiaoning Si, David Marchant, Decheng Yang, Bruce M. McManus, Honglin Luo 267

15 Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease / Nilanjana Maulik 285

16 VEGF Signaling: A Therapeutic Target for Cardiovascular Disease / Dhanya Chandrasekharan Rajalakshmi, Aghila Rani Koippallil Gopalakrishnan, Chandrasekharan Cheranellore Kartha 301

17 Myristoyl-CoA:Protein N-Myristoyltransferase and Myristoyl-CoA Binding Protein from Bovine Cardiac Muscle / Ponniah Selvakumar, Rajendra K. Sharma 327

Part IV Calcium Signaling

18 Ca[superscript 2+]/Calmodulin-Dependent Protein Kinase II Signaling in Vascular Smooth Muscle / Suzanne J. House, Melissa M. Zachar, Roman G. Ginnan, Dee Van Riper, Harold A. Singer 339

19 The KCa3.1 Channel in Endothelial Cells as New Target for an EDHF-Based Control of Vascular Tone: From Structure to Regulation and Pharmacological Properties / Umberto Banderali, Line Garneau, Manuel Simoes, Helene Klein, Remy Sauve 357

Part V Adipokine Signaling

20 Leptin Signaling in the Cardiovascular System / Morris Karmazyn, Daniel M. Purdham, Venkatesh Rajapurohitam, Asad Zeidan 377

21 AMPK Regulation of Cardiac Metabolism in Heart Disease / Ding An, Min-Suk Kim, Brian Rodrigues 397.

Notes:

Includes bibliographical references and index.

ISBN:

9780387095516

0387095519

OCLC:

233934603