Clinical epidemiology : practice and methods / edited by Patrick Parfrey and Brendan Barrett.

Format:

• Book

Contributor:

• Parfrey, Patrick S.
• Barrett, Brendan.

Series:

• Methods in molecular biology (Clifton, N.J.) ; v. 473.
• Methods in molecular biology ; 473

Language:

English

Subjects (All):

• Epidemiology.
• Epidemiology--Methodology.
• Epidemiologic Methods.

Medical Subjects:

• Epidemiology.
• Epidemiologic Methods.

Physical Description:

x, 321 pages : illustrations ; 27 cm.

Place of Publication:

Totowa, N.J. : Humana ; London : Springer [distributor], [2009]

Summary:

Clinical epidemiology provides the scientific basis for the practice of medicine by focusing on the diagnosis, prognosis, and management of human disease using appropriate research design, measurement, and evaluation. In Clinical Epidemiology: Practice and Methods, leading experts educate researchers on how best to undertake clinical research. Divided into two parts, the volume first covers issues of design, measurement, and analysis associated with various research designs, then continues with methods to better inform medical decisionmaking, including aggregation of multiple studies using meta-analysis, health economics, clinical practice guidelines, and health technology assessment. As a part of the highly successful Methods in Molecular Biology series, this comprehensive text collects the kind of detailed, up-to-date information and implementation advice that is crucial for achieving optimal results. Essential and advantageous, Clinical Epidemiology: Practice and Methods is an ideal reference for medical practitioners, basic scientists, and allied health professionals who desire to improve clinical outcomes.

Contents:

• 1 On Framing the Research Question and Choosing the Appropriate Research Design / Patrick Parfrey, Pietro Ravani 1
• 2 Longitudinal Studies and Determination of Risk / Sean W. Murphy 19
• 3 Modeling Longitudinal Data, I: Principles of Multivariate Analysis / Pietro Ravani, Brendan Barrett, Patrick Parfrey 39
• 4 Modeling Longitudinal Data, II: Standard Regression Models and Extensions / Pietro Ravani, Brendan Barrett, Patrick Parfrey 61
• 5 The Design of Randomized Controlled Trials / Bryan M. Curtis, Brendan J. Barrett, Patrick Parfrey 95
• 6 Analysis of Randomized Controlled Clinical Trials / Robert N. Foley 113
• 7 Evaluation of Diagnostic Tests / John M. Fardy 127
• 8 Biomarkers and Surrogates in Clinical Studies / Claudio Rigatto, Brendan J. Barrett 137
• 9 Measurement and Analysis of Patient-Reported Outcomes / Klemens B. Meyer, Kimberly A. Clayton 155
• 10 Bias in Clinical Studies of Genetic Diseases / Susan Stuckless, Patrick Parfrey 171
• 11 Genetic Epidemiology of Complex Phenotypes / Lynette Peddle, Proton Rahman 187
• 12 Qualitative Research in Clinical Epidemiology / Deborah M. Gregory, Christine Y. Way 203
• 13 Primer on Systematic Review and Meta-Analysis / Marcello Tonelli, Dan Hackman, Amit X. Garg 217
• 14 The Role of Health Economics within Clinical Research / Braden J. Manns 235
• 15 Development and Limitations of Clinical Practice Guidelines / Bruce Culleton 251
• 16 Basics of Health Technology Assessment / Daria O'Reilly, Kaitryn Campbell, Ron Goeree 263
• 17 Research Ethics for Clinical Researchers / John D. Harnett, Richard Neuman 285
• 18 Budgeting, Funding and Managing Clinical Research Projects / Elizabeth Hatfield, Elizabeth Dicks, Patrick Parfrey 299.

Notes:

• "Springer protocols"--Cover.
• Includes bibliographical references and index.

ISBN:

• 9781588299642
• 1588299643

OCLC:

227277709