Animal models of acute neurological injuries / edited by Jun Chen ... [and others].

Format:

Book

Contributor:

Chen, Jun.

Language:

English

Subjects (All):

Animal models.

Nervous system--Wounds and injuries--Animal models.

Nervous system.

Nervous System--pathology.

Models, Animal.

Nervous system--Wounds and injuries.

Medical Subjects:

Nervous System--pathology.

Models, Animal.

Physical Description:

xxi, 498 pages : illustrations (some color) ; 27 cm

Place of Publication:

Totowa, NJ : Humana Press, [2009]

Summary:

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Contents:

Part I Animal Care and Surgery

1 Animal Protocol / Laurel D. Schantz 3

2 Anesthesia and Analgesia for Research Animals / Andrew R. Blickman, Lisa J. Brossia 11

3 Rodent Surgical Procedures and Tissue Collection / Robert Ayer, Julian Cahill, Takashi Sugawara, Vikram Jadhav, John H. Zhang 19

4 Brain Monitoring / Julian Cahill, John H. Zhang 39

5 Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies / Aaron H. Puckett, Christine D. Nunn, Stephen M. Onifer 47

Part II Cerebral Ischemic Animal Models

Section I Global Cerebral Ischemic Models

6 Four-Vessel Occlusion Model in Rats / Ping Deng, Zao C. Xu 65

7 Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia / Ami P. Raval, Chunli Liu, Bingren R. Hu 77

8 Asphyxial Cardiac Arrest / Clifton W. Callaway, Eric S. Logue 87

9 Rodent Model of Pediatric Asphyxial Cardiac Arrest / Mioara D. Manole, Robert W. Hickey, Henry L. Alexander, Robert S.B. Clark 103

10 Transient Global Cerebral Ischemia Model in Mice / Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga, Pak H. Chan 115

Section II Focal Cerebral Ischemic Models

11 Transient Middle Cerebral Artery Occlusion Model in Rodents / Ying Mao, Wei Zhu, Guo-Yuan Yang 129

12 Three-Vessel Middle Cerebral Artery Occlusion Model / T.N. Lin, S.T. Chen, Y.Y. He, W.M. Cheung, C.Y. Hsu 141

13 A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA / Yoshihiro Murata, Xiaoying Wang, Eng H. Lo 155

14 Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption / David Kleinfeld, Beth Friedman, Patrick D. Lyden, Andy Y. Shih 169

15 Middle Cerebral Artery Occlusion Suture Model for Mice / Feng Zhang, Steven H. Graham, Jun Chen 187

16 Intraluminal Middle Cerebral Artery Occlusion Model in Mice / Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi, Hiroyuki Kinouchi 197

17 Cerebral Hypoxia-Ischemia Model in Adult Mice / Faisal Adhami, Chia-Yi Kuan 207

Section III Neonatal Hypoxia-Ischemia

18 Cerebral Hypoxia-Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury / Changlian Zhu, Xiaoyang Wang, Klas Blomgren 221

19 Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits / X. Ji, M. Derrick, S. Tan 231

20 Model of Neonatal Focal Cerebral Ischemia-Reperfusion / Zinaida S. Vexler, Donna M. Ferriero 247

Part III Cerebral Hemorrhage Animal Models

Section I Subarachnoid Hemorrhage

21 Monofilament Perforation Subarachnoid Hemorrhage Rat Model / Julian Chaill, John H. Zhang 261

22 Blood Injection Subarachnoid Hemorrhage Rat Model / Hartmut Vatter, Erdem Gueresir, Volker Seifert 271

23 Filament Perforation Subarachnoid Hemorrhage: Mouse Model / Hideyuki Kamii, Teiji Tominaga 279

24 Blood Injection Subarachnoid Hemorrhage Mouse Model / Tarkan Calisaneller, Chih-Lung Lin, Naoya Ukita, Ryo Yoshimura, Yi Wang, Mark Fitzgerald, Kevin S. Lee 287

Section II Cerebral Vasospasm

25 Blood Injection Cerebral Vasospasm Rabbit Model / Mario Zuccarello 295

26 Double Blood-Injection Cerebral Vasospasm Canine Model / Shigeru Nishizawa 301

27 Nonhuman Primate Blood-Clot Placement Cerebral Vasospasm Model / Ayako Kawashima, R. Loch Macdonald 315

Section III Intracerebral Hemorrhage

28 Blood Injection Intracerebral Hemorrhage Rat Model / Thomas O'Lynnger, Ya Hua, Guohua Xi 331

29 Bacterial Collagenase Injection Intracerebral Hemorrhage Rat Model / Mark Grossetete, Gary A. Rosenberg 337

30 Blood Injection Intracerebral Hemorrhage Mouse Model / Ludmila Belayev 349

31 Blood Injection Intracerebral Hemorrhage Pig Model / Ya Hua, Yuxiang Gu, Guohua Xi 359

Part IV Traumatic CNS Injury Animal Models

Section I Experimental Brain Injury Models

32 Fluid Percussion Injury Model / Jonathan Lifshitz 369

33 Controlled Cortical Impact Injury Model / C. Edward Dixon, Anthony E. Kline 385

34 Marmarou Weight Drop Injury Model / Christina R. Marmarou, Ruth Prieto, Keisuke Taya, Harold F. Young, Anthony Marmarou 393

Section II Experimental Spinal Cord Injury Models

35 MASCIS Spinal Cord Contusion Model / Wise Young 411

36 Infinite Horizon Spinal Cord Contusion Model / Stephen Scheff, Kelly N. Roberts 423

37 The Ohio State University ESCID Spinal Cord Contusion Model / Lyn B. Jakeman, Dana M. McTigue, Patricia Walters, Bradford T. Stokes 433

38 Acute Clip Impact-Compression Model / Charles H. Tator, Peter Poon 449

39 Experimental Laceration Spinal Cord Injury Model / Yi Ping Zhang, Lisa B.E. Shields, Christopher B. Shields 461

40 Rodent Spinal Cord Demyelination Models / Sarah C. Jernigan, Yi Ping Zhang, Christopher B. Shields, Scott R. Whittemore 471

41 Spinal Cord Lateral Hemisection and Implantation of Guidance Channels / Xiaofei Wang, Xiao-Ming Xu 479

42 Spinal Root Avulsion and Repair Model / Tak-Ho Chu, Wutian Wu 487.

Notes:

Includes bibliographical references and index.

ISBN:

9781603271844

1603271848

OCLC:

233933724