EGFR signaling networks in cancer therapy / edited by John D. Haley, William John Gullick.

Format:

Book

Contributor:

Haley, John D.

Gullick, William John.

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Cancer--Chemotherapy.

Neoplasms--therapy.

Neoplasms--drug therapy.

Medical Subjects:

Neoplasms--therapy.

Neoplasms--drug therapy.

Physical Description:

xi, 393 pages, 1 unnumbered leaf of plates : illustrations (partly color) ; 26 cm.

Other Title:

Epidemeral growth factor receptor signaling networks in cancer therapy

Place of Publication:

New York : Humana Press, 2007.

Summary:

The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. EGFR Signaling Networks in Cancer Therapy is separated into two sections, the first of which probes the molecular pathways and the intersection of signaling networks, which are frequently deregulated in human cancers, with a view to describing the EGF receptor in a tumor tissue-specific context. The second section illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system and provides compelling information. Probes the molecular pathways and the intersection of signaling networks, which are frequently deregulated in human cancers, Describes EGF receptor in a tumor tissue-specific context, Illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial-to-mesenchymal transition and metastasis.

Contents:

Section I EGFR Signaling Networks

1 EGF Receptor Family Extracellular Domain Structures and Functions / Antony W. Burgess, Thomas P.J. Garrett 3

2 EGFR Family Heterodimers in Cancer Pathogenesis and Treatment / Howard M. Stern 15

3 Structure-function of EGFR Kinase Domain and Its Inhibitors / Charles Eigenbrot 31

4 Internalization and Degradation of the EGF Receptor / Alexander Sorkin 47

5 Differential Dependence of EGFR and ErbB2 on the Molecular Chaperone Hsp90 / Wanping Xu, Len Neckers 63

6 Activation of STATs 3 and 5 Through the EGFR Signaling Axis / Priya Koppikar, Jennifer Rubin Grandis 73

7 The Intersection of EGFR and the Ras Signaling Pathway / Marie Wislez, Jonathan M. Kurie 89

8 Phosphoinositide 3-Kinase Enzymes as Downstream Targets of the EGF Receptor / Jan Domin 97

9 Convergence of EGF Receptor and Src Family Signaling Networks in Cancer / Jessica E. Pritchard, Allison B. Jablonski, Sarah J. Parsons 119

10 A Molecular Crosstalk between E-cadherin and EGFR Signaling Networks / Julie Gavard, J. Silvio Gutkind 139

11 Crosstalk Between Insulin-like Growth Factor (IGF) and Epidermal Growth Factor (EGF) Receptors / Marc A. Becker, Douglas Yee 155

12 Negative Regulation of Signaling by the EGFR Family / Kermit L. Carraway, III, Lily Yen, Ellen Ingalla, Colleen Sweeney 169

13 Nuclear ErbB Receptors: Pathways and Functions / Hong-Jun Liao, Graham Carpenter 187

14 Temporal Dynamics of EGF Receptor Signaling by Quantitative Proteomics / Blagoy Blagoev, Irina Kratchmarova, Jesper V. Olsen, Matthias Mann 199

15 Computational and Mathematical Modeling of the EGF Receptor System / Colin G. Johnson, Emmet McIntyre, William Gullick 209

Section II EGFR in Tumorigenesis and EGFR Tyrosine Kinase Inhibitors in Cancer Therapy

16 Expression and Prognostic Significance of the EGFR in Solid Tumors / Nicola Normanno, Caterina Bianco, Antonella De Luca, Luigi Strizzi, Marianna Gallo, Mario Mancino, David S. Salomon 221

17 Signaling by the EGF Receptor in Human Cancers: Accentuate the Positive, Eliminate the Negative / Haley L. Bennett, Tilman Brummer, Paul Timpson, Kate I. Patterson, Roger J. Daly 235

18 EGFR Signaling in Invasion, Angiogenesis and Metastasis / Carol Box, Joanna Peak, Susanne Rogers, Suzanne Eccles 257

19 Constitutive Activation of Truncated EGF Receptors in Glioblastoma / Carol J. Wikstrand, Darell D. Bigner 277

20 EGFR Mutations, Other Molecular Alterations Related to Sensitivity to EGFR Inhibitors, and Molecular Testing for EGFR-Targeted Therapies in Non-Small Cell Lung Cancer / David A. Eberhard 293

21 Crosstalk Between COX-2 and EGFR: A Potential Therapeutic Opportunity / Andrew J. Dannenberg, Kotha Subbaramaiah 337

22 Cellular Sensitivity to EGF Receptor Inhibitors / Stuart Thomson, John D. Haley, Robert Yauch 353

23 Utilizing Combinations of Molecular Targeted Agents to Sensitize Tumor Cells to EGFR Inhibitors / Elizabeth Buck, Alexandra Eyzaguirre, Kenneth K. Iwata 369.

Notes:

Includes bibliographical references and index.

ISBN:

9781588299482

1588299481

OCLC:

166358009