Computational methods for understanding bacterial and archaeal genomes / editors, Ying Xu, J. Peter Gogarten.

Format:

Book

Contributor:

Xu, Ying, 1960-

Gogarten, J. Peter.

Series:

Series on advances in bioinformatics and computational biology ; v. 7.

Series on advances in bioinformatics and computational biology

Language:

English

Subjects (All):

Microbial genetics--Data processing--Textbooks.

Microbial genetics.

Bacterial genomes--Data processing--Textbooks.

Bacterial genomes.

Prokaryotes--Textbooks.

Prokaryotes.

Computational biology--Textbooks.

Computational biology.

Genetics, Microbial.

Genome, Bacterial.

Computational Biology.

Medical Subjects:

Genetics, Microbial.

Genome, Bacterial.

Computational Biology.

Genre:

Textbooks.

Physical Description:

xix, 473 pages : illustrations (some color) ; 26 cm.

Place of Publication:

London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Publishing, 2008.

Summary:

Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

Contents:

1 General Characteristics of Prokaryotic Genomes / Jan Mrazek, Anne O. Summers 1

2 Genes in Prokaryotic Genomes and Their Computational Prediction / Rajeev K. Azad 39

3 Evolution of the Genetic Code: Computational Methods and Inferences / Greg Fournier 75

4 Dynamics of Prokaryotic Genome Evolution / Pascal Lapierre 99

5 Mobile Genetic Elements and Their Prediction / Morgan G.I. Langille, Fengfeng Zhou, Amber Fedynak, William W.L. Hsiao, Ying Xu, Fiona S.L. Brinkman 113

6 Horizontal Gene Transfer: Its Detection and Role in Microbial Evolution / J. Peter Gogarten, Olga Zhaxybayeva 137

7 Genome Reduction During Prokaryotic Evolution / Francisco J. Silva, Amparo Latorre 153

8 Comparative Mechanisms for Transcription and Regulatory Signals in Archaea and Bacteria / Agustino Martinez-Antonio, Julio Collado-Vides 185

9 Computational Techniques for Orthologous Gene Prediction in Prokaryotes / Maria Poptsova 209

10 Computational Elucidation of Operons and Uber-operons / Phuongan Dam, Fenglou Mao, Dongsheng Che, Ping Wan, Thao Tran, Guojun Li, Ying Xu 233

11 Prediction of Regulons Through Comparative Genome Analyses / Zhengchang Su, Guojun Li, Ying Xu 259

12 Prediction of Biological Pathways Through Data Mining and Information Fusion / Fenglou Mao, Phuongan Dam, Hongwei Wu, I-Chun Chou, Eberhard Voit, Ying Xu 281

13 Microbial Pathway Models / Siren R. Veflingstad, Phuongan Dam, Ying Xu, Eberhard O. Voit 315

14 Metagenomics / Kayo Arima, John Wooley 345.

Notes:

Includes bibliographical references (pages 397-466) and index.

ISBN:

1860949827

9781860949821

OCLC:

191658532