Animal hematotoxicology : a practical guide for toxicologists and biomedical researchers / G. O. Evans.

Format:

Book

Author/Creator:

Evans, G. O.

Contributor:

Hazel M. Hussong Fund.

Language:

English

Subjects (All):

Toxicology, Experimental.

Hematology, Experimental.

Laboratory animals.

Animals, Laboratory--blood.

Toxicology--methods.

Hematologic Tests--methods.

Hematology--methods.

Predictive Value of Tests.

Toxicity Tests--methods.

Medical Subjects:

Animals, Laboratory--blood.

Toxicology--methods.

Hematologic Tests--methods.

Hematology--methods.

Predictive Value of Tests.

Toxicity Tests--methods.

Physical Description:

xiii, 206 pages : illustrations ; 25 cm

Place of Publication:

Boca Raton : CRC Press, [2009]

Summary:

When looking for books in this field, you may find multidisciplinary books with chapters on toxicology, major textbooks written primarily about human medicine, or books geared toward the veterinary field, but few that focus on animal hematotoxicology written specifically for laboratory scientists. Until now. Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers explores the intersection of these fields and also those areas where the "rules" for human hematology and toxicology do not always apply.

Features Presents information on main laboratory animal species with tables of reference values, Includes a chapter on bone marrow evaluation containing material on micronucleus tests in genetic toxicology, Explores pre-analytical effects and the common laboratory measurements that indicate fundamental differences in cell counting techniques, Discusses differences between blood cell numbers, shapes, and sizes for laboratory animals, Provides key references on published reference ranges for laboratory animals.

Hematology data from in vivo toxicology studies remains one of, if not the most, predictive indicators for human risk assessment. Toxicological science requires people with the knowledge and experience to interpret and place hematological findings obtained from a study into an overall picture of toxicity. Based on information collated from published papers, textbooks, and unpublished data, this book provides an overview of the discipline, from basic principles to diagnostic evaluation, in a clear and concise manner.

Contents:

Hemopoiesis, blood cell types, and bone marrow examination

Erythrocytes, anemias, and polycythemias

Additional erythrocytic measurements

Iron, associated proteins, and vitamins

Leukocytes

Immunotoxicology

Hemostasis

Preanalytical variables

Analytical variables and biosafety

Data processing and interpretation.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Hazel M. Hussong Fund.

ISBN:

9781420080094

1420080091

OCLC:

226212647