Genetic effects on environmental vulnerability to disease / edited by Michael Rutter.

Format:

Book

Contributor:

Rutter, Michael, 1933-

Novartis Foundation.

Series:

Novartis Foundation symposium ; 293.

Novartis Foundation symposium ; [293]

Language:

English

Subjects (All):

Disease susceptibility--Genetic aspects--Congresses.

Disease susceptibility.

Environmentally induced diseases--Genetic aspects--Congresses.

Environmentally induced diseases.

Environmental Exposure--adverse effects.

Disease susceptibility--Genetic aspects.

Disease Susceptibility--etiology.

Genetic Predisposition to Disease--genetics.

Medical Subjects:

Environmental Exposure--adverse effects.

Disease Susceptibility--etiology.

Genetic Predisposition to Disease--genetics.

Genre:

Conference papers and proceedings.

Physical Description:

viii, 223 pages : illustrations ; 24 cm.

Place of Publication:

Chichester : J. Wiley & Sons, 2008.

Summary:

While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. An alternative is to use a gene-environment interaction approach that focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor.

Genetic Effects on Environmental Vulnerability to Disease is based on the final meeting of the Novartis Foundation Symposium Series (#293 Understanding How Gene Environment Interactions Work to Predict Disorder). Contributions from geneticists, physicians, oncologists, biologists, statisticians, epidemiologists, psychiatrists and psychologists address: how physiological (mechanistic) measures can be better integrated into epidemiological cohort studies, how best to characterise subjects' vulnerability versus resilience by moving beyond genetic main effects, how gene hunters can benefit from recruiting samples selected for known exposures, how environmental pathogens can be used as tools for gene hunting how to deal with potential spurious (statistical) interactions, and, how genes can help explain fundamental demographic properties of disorders such as sex distribution or age effects.

Interwoven with transcripts of the lively discussions among researchers, the book offers a cutting-edge review of the methodological issues prevailing in this complex, multi-disciplinary field. A glossary is included to facilitate inter-disciplinary understanding, and Sir Michael Rutter's introduction and concluding remarks contribute to presenting scientific issues in an interesting, easily accessible manner.

This book will be of interest to epidemiologists, geneticists, developmental biologists, and researchers in psychiatric disorders, obesity, diabetes, cancer, respiratory diseases and cardiovascular disease.

Contents:

Introduction : whither gene-environment interactions? ? Michael Rutter

Gene-environment interaction : overcoming methodological challenges / Rudolf Uher

Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato

Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin

Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman

Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge

Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson

Longitudinal studies of gene-environment interaction in common diseases - good value for money? / Stephen P. Robertson and Richie Poulton

Gene-environment interactions in breast cancer / Kee-Seng Chia

Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu

Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho

Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez

Conclusions : taking stock and looking ahead / Michael Rutter.

Notes:

"Symposium on understanding how gene-environment interactions work to predict disorder: a lifecourse approach, held at The University of Central Otago, Dunedin, New Zealand, 8-9 November 2007" -- p. vii.

Includes bibliographical references and indexes.

ISBN:

9780470777800

047077780X

OCLC:

232712377