Beyond apoptosis : cellular outcomes of cancer therapy / edited by Igor B. Roninson, J. Martin Brown, Dale E. Bredesen.

Format:

Book

Contributor:

Roninson, Igor B.

Brown, J. M. (J. Martin)

Bredesen, Dale E.

Language:

English

Subjects (All):

Cancer--Chemotherapy.

Cancer.

Apoptosis.

Neoplasms--drug therapy.

Antineoplastic Agents.

Apoptosis--drug effects.

Cellular Senescence--drug effects.

Mitosis--drug effects.

Medical Subjects:

Neoplasms--drug therapy.

Antineoplastic Agents.

Apoptosis--drug effects.

Cellular Senescence--drug effects.

Mitosis--drug effects.

Physical Description:

xi, 352 pages : illustrations ; 24 cm + 1 DVD (color ; 4 3/4 in.)

Place of Publication:

New York : Informa Healthcare, [2008]

Summary:

Accompanying DVD contains ... "additional color images and video clips from time-lapse microscopic studies of different forms of cell death and mitotic catastrophe."--P. iv.

Contents:

A personal history of the development of the apoptosis concept / John F.R. Kerr

What do the clinical data tell us about the role of apoptosis in sensitivity to cancer therapy? / George D. Wilson

Response of solid tumors to cancer therapy: how relevant is apoptosis? / J. Martin Brown

Historical studies of various forms of programmed cell death / Richard A. Lockshin and Zahra Zakeri

Toward a mechanistic taxonomy for programmed cell death pathways / Dale E. Bredesen

Caspase-independent apoptotic cell death / Lotti Egger

Autophagic cell death in mammalian cells / David T. Madden

The cellular decision between apoptosis and autophagy / Yongjun Fan, Erica Ullman, and Wei-Xing Zong

Parthanatos: PARP- and AIF-dependant programmed cell death / Valina L. Dawson and Ted M. Dawson

Paraptosis / Sabina Sperandio and Ian de Belle

Cellular senescence and its effects on carcinogenesis / Judith Campisi

Tumor-suppressing activities of senescent keratinocytes / Brian J. Nickoloff

Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells / Daniel DiMaio ... [et al.]

Treatment-induced tumor cell senescence and its consequences / Igor B. Roninson and Eugenia V. Broude

Senescence regulation in cancer therapy / Abdelhadi Rebbaa

Exploiting drug-induced senescence in transgenic mouse models / Mehtap Kilic and Clemens A. Schmitt

Therapy-induced cellular senescence: clinical relevance, implications, and applications / Daniel Y. Wu ... [et al.]

Mitotic catastrophe in cancer therapy / Eugenia V. Broude ... [et al.]

How do cells die after irradiation? Time-lapse studies of cells in culture / William C. Dewey

Modes of cell death by anticancer agents: the crucial importance of dose / J. Martin Brown.

Notes:

Includes bibliographical references and index.

ISBN:

9780849391927

084939192X

OCLC:

144565832