Essentials of clinical research / Stephen P. Glasser, editor.

Format:

Book

Contributor:

Glasser, Stephen P., 1940-

Language:

English

Subjects (All):

Clinical medicine--Research.

Clinical medicine.

Clinical Medicine.

Research Design.

Medical Subjects:

Clinical Medicine.

Research Design.

Physical Description:

xv, 360 pages : illustrations (partly color) ; 24 cm

Place of Publication:

[New York] : Springer, [2008]

Summary:

This book is designed to provide the "student" interested in clinical research, a foundation upon which to build more advanced study. The book focuses on clinical trials, in contrast to the many excellent textbooks that address epidemiological research. With the recent interest in patient oriented research, this book should provide a knowledge base that is not necessarily covered in other texts. Chapters discussing the FDA's role in clinical research, Data Safety and Monitoring Boards, Postmarketing studies, the use of placebo controls, and a focus on clinical trials illustrates this point. In addition, new types of clinical research are evolving, and as such, this book discusses genetic, pharmacoepidemiologic, and implementation research. Finally, chapters on tips on how to write a grant, the mentoring process, and how to present one's research results are unique to this book.

Contents:

1 Clinical Research: Definitions, "Anatomy and Physiology," and the Quest for "Universal Truth" / Stephen P. Glasser 3

2 Introduction to Clinical Research and Study Designs / Stephen P. Glasser 13

3 Clinical Trials / Stephen P. Glasser 29

4 Alternative Interventional Study Designs / Stephen P. Glasser 63

5 Postmarketing Research / Stephen P. Glasser, Elizabeth Delzell, Maribel Salas 73

6 The United States Federal Drug Administration (FDA) and Clinical Research / Stephen P. Glasser, Carol M. Ashton, Nelda P. Wray 93

7 The Placebo and Nocebo Effect / Stephen P. Glasser, William Frishman 111

8 Recruitment and Retention / Stephen P. Glasser 141

9 Data Safety and Monitoring Boards (DSMBs) / Stephen P. Glasser, O. Dale Williams 151

10 Meta-Analysis / Stephen P. Glasser, Sue Duval 159

11 Research Methods for Genetic Studies / Sadeep Shrestha, Donna K. Arnett 181

12 Research Methods for Pharmacoepidemiology Studies / Maribel Salas, Bruno Stricker 201

13 Implementation Research: Beyond the Traditional Randomized Controlled Trial / Amanda H. Salanitro, Carlos A. Estrada, Jeroan J. Allison 217

14 Research Methodology for Studies of Diagnostic Tests / Stephen P. Glasser 245

15 Statistical Power and Sample Size: Some Fundamentals for Clinician Researchers / J. Michael Oakes 261

16 Association, Cause, and Correlation / Stephen P. Glasser, Gary Cutter 279

17 Bias, Confounding, and Effect Modification / Stephen P. Glasser 295

18 It's All About Uncertainty / Stephen P. Glasser, George Howard 303

19 Grant Writing / Donna K. Arnett, Stephen P. Glasser 317

20 The Media and Clinical Research / Stephen P. Glasser 329

21 Mentoring and Advising / Stephen P. Glasser, Edward W. Hook III 335

22 Presentation Skills: How to Present Research Results / Stephen P. Glasser 341.

Notes:

Includes bibliographical references and index.

ISBN:

9781402084850

1402084854

9781402084867

1402084862

OCLC:

262209297