High-throughput analysis in the pharmaceutical industry / edited by Perry G. Wang.

Format:

Book

Contributor:

Wang, Perry G.

Alumni and Friends Memorial Book Fund.

Series:

Critical reviews in combinatorial chemistry

Language:

English

Subjects (All):

High throughput screening (Drug development).

Combinatorial chemistry.

Combinatorial Chemistry Techniques--methods.

Drug Design.

Pharmaceutical Preparations--analysis.

Technology, Pharmaceutical--methods.

Medical Subjects:

Combinatorial Chemistry Techniques--methods.

Drug Design.

Pharmaceutical Preparations--analysis.

Technology, Pharmaceutical--methods.

Physical Description:

413 pages : illustrations ; 26 cm.

Place of Publication:

Boca Raton, FL : CRC Press, [2009]

Summary:

The introduction of combinatorial chemistry technology has increased the number of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvement to the conventional methodology must happen. Written and edited by well-known contributors still active in this line of research, High-Throughput Analysis in the Pharmaceutical Industry focuses on automated sample preparation and high-throughput analysis by high-performance liquid chromatography (HPLC) and mass spectrometry (MS).

Features Examines the important role high-throughput analysis plays in successful drug discovery and development, Provides a systematic description of high-throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation, Explores strategies for optimizing techniques such as high-performance liquid chromatography combined with mass spectrometry (HPLC-MS) or tandem mass spectrometry (HPLC-MS-MS), Introduces microparallel liquid chromatography (LC), ADME/PK high-throughput assay, MS-based proteomics, and the advances of capillary and nano-HPLC technology.

Ever-shortening timelines and high costs make the need for high throughput approaches to currently used methods increasingly obvious and imperative. The critical role high-throughput technologies play in the pharmaceutical industry, and the increased attention they receive, put them on the leading edge of analytical techniques. Packed with practical examples, this book examines new analytical techniques and provides guidance in their use in drug discovery and development.

Contents:

High-throughput sample preparation techniques and their application to bioanalytical protocols and purification of combinatorial libraries / Krishna Kallury

Online sample extraction coupled with multiplexing strategy to improve throughput / Katty X. Wan

Optimizing LC/MS equipment to increase throughput in pharmaceutical analysis / Michael G. Frank and Douglas E. McIntyre

Throughput improvement of bioanalytical LC/MS/MS by sharing detector between HPLC systems / Min Shuan Chang and Tawakol El-Shourbagy

High-throughput strategies for metabolite identification in drug discovery / Patrick J. Rudewicz, Qin Yue, and Young Shin

Utilizing microparallel liquid chromatography for high-throughput analyses in the pharmaceutical industry / Sergio A. Guazzotti

Strategies and techniques for higher throughput ADME/PK assays / Walter Korfmacher

High-throughput analysis in drug metabolism during early drug discovery / Yau Yi Lau

High-throughput analysis in the support of process chemistry and formulation research and development in the pharmaceutical industry / Zhong Li

Online solid phase extraction LC/MS/MS for high-throughput bioanalytical analysis / Dong Wei and Liyu Yang

Applications of high-throughput analysis in therapeutic drug monitoring / Quanyun A. Xu and Timothy L. Madden

High-throughput quantitative pharmaceutical analysis in drug metabolism and pharmacokinetics using liquid chromatography-mass spectrometry / Xiaohui Xu

Designing high-throughput HPLC assays for small and biological molecules / Roger K. Gilpin and Wanlong Zhou

Advances in capillary and nano HPLC technology for drug discovery and development / Frank J. Yang and Richard Xu

High-throughput analysis of complex protein mixtures by mass spectrometry / Kojo S.J. Elenitoba-Johnson.

Notes:

Errata slip inserted.

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

9781420059533

142005953X

OCLC:

191751611

Online:

Publisher description