Nucleic acids in innate immunity / edited by Ken J. Ishii, Shizuo Akira.

Format:

Book

Contributor:

Ishii, Ken J.

Akira, S.

Language:

English

Subjects (All):

Natural immunity.

Nucleic acids.

Immunity, Innate--physiology.

Autoimmunity.

DNA--immunology.

RNA--immunology.

Receptors, Pattern Recognition--immunology.

Self Tolerance.

Medical Subjects:

Immunity, Innate--physiology.

Autoimmunity.

DNA--immunology.

RNA--immunology.

Receptors, Pattern Recognition--immunology.

Self Tolerance.

Physical Description:

xv, 286 pages : illustrations ; 25 cm

Place of Publication:

Boca Raton : CRC Press, [2008]

Summary:

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

Drawing on the research of leading experts in this new area of immunology, Nucleic Acids in Innate Immunity- Describes the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR), Discusses how PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways, Focuses on the therapeutic applications of immunomodulatory DNA to prevent or treat infectious diseases, allergic disorders, and cancer, Addresses how the immune system discriminates self and non-self RNA, Investigates exactly what elements within DNA or RNA are recognized by the innate immune system, Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

Contents:

Structural analysis of toll-like receptors / Jungwoo Choe and Ian A. Wilson

Antiviral signaling through TLRs and RLHs / Taro Kawai

Recognition of virus invasion by toll-like receptors and RIG-I-like helicases / Hiroki Kato and Osamu Takeuchi

Characteristics of dendritic cell responses to nucleic acids / Tsuneyasu Kaisho, Takahiro Sugiyama, and Katsuaki Hoshino

Dendritic cells as sensors for foreign and self nucleic acids / Anne Krug and Wolfgang Reindl

Natural DNA recognition by toll-like receptor 9 does not reply upon CpG motifs: role of endosomal compartmentation / Tobias Haas ... [et al.]

Discrimination of self and non-self DNA / Katryn J. Stacey ... [et al.]

Therapeutic potential of immunosuppressive oligonucleotides expressing TTAGGG motifs / Dennis M. Klinman ... [et al.]

Structure/function of IFNα-inducing CpG ODN / Daniela Verthelyi and Montserrat Puig

Clinical development of oligodeoxynucleotide TLR9 agonists / Julie L. Himes and Arthur M. Krieg

Prospects for TLR9- based immunotherapy for asthma and allergy / David Broide

Toll-like receptors in the development of systemic autoimmune disease: in vitro artifact or in vivo paradigm? / Ann Marshak-Rothstein and Mark J. Shlomchik

Impacts of nucleoside modification on RNA-mediated activation of toll-like receptors / Katalin Karikó and Drew Weissman

Activation of innate pattern recognition pathways by single-stranded ribonucleic acids / Sandra S. Diebold

RNA interference in scope of immune system / Andrea Ablasser, Gunther Hartmann, and Veit Hornung

Recognition of RNA and synthetic compounds by TLR7 and TLR8 / Svetlana Hamm and Stefan Bauer

Helicases at frontline of RNA virus recognition / Leonid Gitlin and Marco Colonna.

Notes:

Includes bibliographical references and index.

ISBN:

9781420068252

1420068253

OCLC:

181862810