Nanotechnology and tissue engineering : the scaffold / Cato T. Laurencin, Lakshmi S. Nair [editors].

Format:

Book

Contributor:

Laurencin, Cato T.

Nair, Lakshmi S.

Language:

English

Subjects (All):

Tissue engineering.

Nanotechnology.

Biomedical materials.

Tissue Engineering--methods.

Nanostructures.

Tissue Scaffolds.

Medical Subjects:

Tissue Engineering--methods.

Nanostructures.

Nanotechnology.

Tissue Scaffolds.

Physical Description:

xvii, 359 pages, 6 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

Boca Raton : CRC Press, [2008]

Summary:

Nanofabrication gives us the ability to mimic biological structures with molecular level precision. Offering a natural progression of topics, Nanotechnology and Tissue Engineering: The Scaffold provides a state-of-the-art account of groundbreaking research in this rapidly emerging area of biomedical engineering.

Emphasizing the importance of scaffolds, the book details fundamental and advanced aspects of nanofabrication and examines cellular interactions at the nanoscale level. It reviews extracellular matrix structure and function and discusses various nanoscale biological surface modifications that can improve cellular responses. The editors present the most promising nanofabrication techniques, including electrospinning, lithography, and self assembly. Featuring the contributions of pioneering scientists writing about their own research, this cutting-edge volume: Provides background information discussing the emerging importance of scaffolds in tissue engineering, Examines tissue engineering as it relates to orthopedic, cardiovascular, neural, and musculoskeletal applications, Details cell responses to a number of nanoscale features, Delves into microfabrication techniques in scaffold development, Presents research on designer self-assembling peptide scaffolds.

This highly comprehensive resource also discusses clinical implications and applications, presenting exciting breakthroughs in neural, vascular, and musculoskeletal tissue engineering with nanostructures. An essential resource for biomedical engineers working on the frontiers of tissue research, this book brings together current findings and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues.

Contents:

Section I Importance of Scaffolds in Tissue Engineering

Chapter 1 Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century / Fan Yang, William L. Neeley, Michael J. Moore, Jeffrey M. Karp, Anita Shukla, Robert Langer 3

Chapter 2 Top-Down Analysis of a Dynamic Environment: Extracellular Matrix Structure and Function / Mandana Veiseh, Eva A. Turley, Mina J. Bissell 33

Chapter 3 Functions and Requirements of Synthetic Scaffolds in Tissue Engineering / Tejas Shyam Karande, C. Mauli Agrawal 53

Chapter 4 Microfabrication Techniques in Scaffold Development / Christopher J. Bettinger, Jeffrey T. Borenstein, Robert Langer 87

Section II Effect of Nanostructures on Cellular Responses and Tissue Regeneration

Chapter 5 Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective / Batur Ercan, Thomas Webster 123

Chapter 6 Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications / Duron A. Lee, Cato T. Laurencin 163

Section III Promising Nanofabrication Techniques to Develop Scaffolds for Tissue Engineering

Chapter 7 Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration / Syam Prasad Nukavarapu, Sangamesh G. Kumbar, Jonathan G. Merrell, Cato T. Laurencin 199

Chapter 8 Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites / Eunice Phay Shing Tan, Chwee Teck Lim 221

Chapter 9 Electrospinning Techniques to Control Deposition and Structural Alignment of Nanofibrous Scaffolds for Cellular Orientation and Cytoskeletal Reorganization / Joel K. Wise, Michael Cho, Eyal Zussman, Constantine M. Megaridis, Alexander L. Yarin 243

Chapter 10 Nanolithographic Techniques in Tissue Engineering / Benjamin Moody, Gregory S. McCarty 261

Chapter 11 Designer Self-Assembling Peptide Scaffolds for Tissue Engineering and Regenerative Medicine / Akihiro Horii, Xiumei Wang, Shuguang Zhang 283

Section IV Applications of Nanostructured Scaffolds in Biology and Medicine

Chapter 12 Nanotechnologies in Neural Tissue Engineering / Vivek Mukhatyar, Julie Yeh, Ravi Bellamkonda 295

Chapter 13 Nanotechnologies for Cardiovascular Tissue Engineering / Kristen A. Wieghaus, Edward A. Botchwey 311

Chapter 14 Nanostructures for Musculoskeletal Tissue Engineering / Susan Liao, Casey K. Chan, Seeram Ramakrishna 329.

Notes:

Includes bibliographical references and index.

ISBN:

9781420051827

1420051822

OCLC:

214300054