Principles and practice of bioanalysis / [edited by] Richard F. Venn.

Format:

Book

Contributor:

Venn, Richard F., 1949-

Language:

English

Subjects (All):

Drugs--Analysis.

Drugs.

Biomolecules--Analysis.

Biomolecules.

Pharmaceutical Preparations--analysis.

Chromatography, High Pressure Liquid.

Mass Spectrometry.

Pharmaceutical Preparations--metabolism.

Medical Subjects:

Pharmaceutical Preparations--analysis.

Chromatography, High Pressure Liquid.

Mass Spectrometry.

Pharmaceutical Preparations--metabolism.

Physical Description:

xiii, 326 pages : illustrations ; 26 cm

Edition:

Second edition.

Place of Publication:

Boca Raton : CRC Press, [2008]

Summary:

In the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substances.

Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling you to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. They cover a wide range of analytical methods, including mass spectrometry, liquid chromatography, immunoassay, NMR, and gas chromatography.

Presenting the information in an informal and highly accessible style, the book covers the theory and practice of bioanalysis, enabling you to gain maximum benefit and to optimize analytical methods. With practical advice and guidance, it delineates how to develop robust analytical methods for a range of compounds, both natural and synthetic. Using this insight, you can more easily recognize problems and quickly solve them.

Contents:

Physicochemical properties of drugs and metabolites and their impact on bioanalysis / Hugh Wiltshire and Angus Nedderman

Sample preparation / Christopher A. James

Basic HPLC theory and pracice / Andy Gray and Peter Lawrence

HPLC optimisation / David Bakes

HPLC detectors / Kenneth C. Saunders and Richard F. Venn

Gas chromatography: what it is and how we use it / Peter Andrew and Mira V. Doig

Thin-layer chromatography / Hugh Wiltshire and Angus Nedderman

Immunoassay techniques / Richard F. Venn

Automation of sample preparation / Kenneth C. Saunders and Christopher A. James

Fundamental aspects of mass spectrometry / Mira V. Doig and David M. Higton

Quantitative LC-MS / David M. Higton and Mira V. Doig

Mass spectrometric identification of metabolites / Gordon Dear

Nuclear magnetic resonance in drug metabolism / Phil Gilbert

Metabolite isolation / Gordon Dear, Angus Neddermann, and Hugh Wiltshire

Strategy for the development of quantitative bioanalytical procedures / David Bakes.

Notes:

Includes bibliographical references and index.

ISBN:

9780849338571

0849338573

OCLC:

157002735

Online:

Publisher description