Protein-protein interactions as new drug targets / Enno Klussmann, John Scott, editors ; contributors, E.M. Aandahl ... [and others].

Format:

Book

Contributor:

Klussmann, Enno.

Scott, John, Ph. D.

Aandahl, E. M.

Series:

Handbook of experimental pharmacology 0171-2004 ; v. 186.

Handbook of experimental pharmacology, 0171-2004 ; v. 186

Language:

English

Subjects (All):

Protein Binding--physiology.

Drug Design.

Intracellular Signaling Peptides and Proteins.

Protein Interaction Mapping.

Drug targeting.

Protein-protein interactions.

Medical Subjects:

Protein Binding--physiology.

Drug Design.

Intracellular Signaling Peptides and Proteins.

Protein Interaction Mapping.

Physical Description:

xv, 512 pages : illustrations ; 24 cm.

Place of Publication:

Berlin : Springer, [2008]

Contents:

Part I Organization of Scaffolds

A-Kinase Anchoring Proteins as the Basis for cAMP Signaling / K.L. Dodge-Kafka, A. Bauman, M.S. Kapiloff 3

Arrestins as Multi-Functional Signaling Adaptors / V.V. Gurevich, E.V. Gurevich, W.M. Cleghorn 15

Role of Ena/VASP Proteins in Homeostasisand Disease / G. Pula, M. Krause 39

Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy / A. Gluch, M. Vidakovic, J. Bode 67

Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? / C. Rodemer, V. Haucke 105

Part II Scaffolding Proteins and Cellular Signalling

PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases / A.C. McCahill, E. Huston, X. Li, M.D. Houslay 125

G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveloae Microdomains / H.H. Patel, F. Murray, P.A. Insel 167

Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function. Implications for Rational Drug Design / J.W. Walker 185

Compartmentalised MAPK Pathways / M.D. Brown, D.B. Sacks 205

Dynamic Protein Complexes Regulate NF-[kappa]B Signaling / E. Wegener, D. Krappmann 237

An Oncogenic Hub: [beta]-Catenin as a Molecular Target for Cancer Therapeutics / K.-I. Takemaru, M. Ohmitsu, F.-Q. Li 261

A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling / M. Berrera, G. Dodoni, S. Monterisi, V. Pertegato, I. Zamparo, M. Zaccolo 285

Part III Cell Type-Specific Anchoring

Scaffolding Proteins in Cardiac Myocytes / N.L. Chudasama, S.O. Marx, S.F. Steinberg 301

Molecular Architecture of Signal Complexes Regulating Immune Cell Function / K.M. Torgersen, E.M. Aandahl, K. Tasken 327

Scaffolding Proteins at the Postsynaptic Density:Shank as the Architectural Framework / H.J. Kreienkamp 365

Part IV Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept

Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies / S. Costa, G. Cesareni 383

Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition / C. Freund, H.G. Schmalz, J. Sticht, R. Kuhne 407

Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors / S.W. Deacon, J.R. Peterson 431

Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs / H.M. Strauss, S. Keller 461

Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets / C. Hundsrucker, E. Klussmann 483.

Notes:

Includes bibliographical references and index.

ISBN:

9783540728429

3540728422

9783540728436

3540728430

OCLC:

212432105