Immunology, phenotype first : how mutations have established new principles and pathways in immunology / Bruce Beutler, editor.

Format:

• Book

Contributor:

• Beutler, Bruce.

Series:

• Current topics in microbiology and immunology ; v. 321.
• Current topics in microbiology and immunology ; v. 321

Language:

English

Subjects (All):

• Immunogenetics.

Medical Subjects:

• Immunogenetics.

Physical Description:

xiii, 220 pages : illustrations (some color) ; 25 cm.

Place of Publication:

Berlin : Springer, [2008]

Summary:

• This monograph deals with the impact of classical genetics in immunology, providing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who don't fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. "Why bother with classical genetics," they may ask. "Won't all genes be knocked out soon anyway?" Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. "What has C. elegans to do with me?" they may ask. "It doesn't even have lymphocytes." They may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind.
• The stories told in this book are some of the most important in immunology. Each begins with phenotype and comes to a profound conclusion about cause. In some cases autoimmunity was at issue; in others cancer; in others a failure to detect or respond to infection. But in all instances, the biological function of a given protein or protein family was discovered. Finding the mechanism through which that protein functions presents the next challenge, and in all cases, the challenge has yet to be met in full.

Contents:

• Part I Immunodeficiency
• The Forward Genetic Dissection of Afferent Innate Immunity / B. Beutler, E.M.Y. Moresco 3
• Genetic Analysis of Resistance to Infections in Mice: A/J meets C57BL/6J / J.-F. Marquis, P. Gros 27
• Host Defenses Against Human Papillomaviruses: Lessons from Epidermodysplasia Verruciformis / G. Orth 59
• Innate Resistance to Flavivirus Infections and the Functions of 2'-5' Oligoadenylate Synthetases / T. Mashimo, D. Simon-Chazottes, J.-L. Guenet 85
• Cmv1 and Natural Killer Cell Responses to Murine Cytomegalovirus Infection / A.A. Scalzo, W.M. Yokoyama 101
• Genetic Dissection of Host Resistance to Mycobacterium tuberculosis: The sst1 Locus and the Ipr1 Gene / I. Kramnik 123
• Part II Self-Reactivity
• Scurfy, the Foxp3 Locus, and the Molecular Basis of Peripheral Tolerance / M.W. Appleby, F. Ramsdell 151
• Fevers, Genes, and Innate Immunity / J.G. Ryan, D.L. Kastner 169
• Itchy Mice: The Identification of a New Pathway for the Development of Autoimmunity / L.E. Matesic, N.G. Copeland, N.A. Jenkins 185
• TIM Gene Family and Their Role in Atopic Diseases / D.T. Umetsu, S.E. Umetsu, G.J. Freemen, R.H. DeKruyff 201.

Notes:

Includes bibliographical references and index.

ISBN:

• 9783540752028
• 3540752021
• 354075203X
• 9783540752035

OCLC:

229038944