Computational systems bioinformatics : methods and biomedical applications / Xiaobo Zhou, Stephen T. C. Wong.

Format:

Book

Author/Creator:

Zhou, Xiaobo

Contributor:

Wong, Stephen T. C.

Language:

English

Subjects (All):

Computational biology.

DNA microarrays.

Bioinformatics.

Computational Biology--methods.

Microarray Analysis--methods.

Oligonucleotide Array Sequence Analysis--methods.

Statistics as Topic--methods.

Medical Subjects:

Computational Biology--methods.

Microarray Analysis--methods.

Oligonucleotide Array Sequence Analysis--methods.

Statistics as Topic--methods.

Physical Description:

x, 387 pages : illustrations (partly color) ; 24 cm

Place of Publication:

Singapore ; Hackensack, N.J. : World Scientific, [2008]

Summary:

Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing either on information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields.

This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step by step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Contents:

Mathematical, statistical, and data mining principles

Missing value estimation using KNN and Bayesian methods

Normalization, scaling, and discretization

Cross-platform comparison

Discovering differential biomarkers

Gene selection and classification

Gene clustering

Gene prediction.

Reverse engineering: gene regulatory network construction and its behavior

Motif detection and transcription factor binding site (TFBS) identification

Integrated microarray and gene sequence analysis

Protein structure informatics

Biomarker discovery from proteomics

Bioimaging informatics

Conclusions.

Notes:

Includes bibliographical references and index.

ISBN:

9789812707048

9812707042

OCLC:

171258229