Structural and functional organization of the synapse / edited by Johannes W. Hell and Michael D. Ehlers.

Format:

Book

Contributor:

Hell, Johannes W.

Ehlers, Michael D.

Language:

English

Subjects (All):

Synapses.

Medical Subjects:

Synapses.

Physical Description:

xviii, 801 pages : illustrations (some color), color portrait ; 25 cm

Place of Publication:

New York : Springer, [2008]

Summary:

Synapses play a central role in the brain by mediating signal transmission between neurons. Structural and Functional Organization of the Synapse provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement.

This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain's fundamental unit of information storage.

Contents:

Diversity in Synapse Structure and Composition / Kristen M. Harris 1

The Role of Glutamate Transporters in Synaptic Transmission / Dwight E. Bergles, Robert H. Edwards 23

Structure and Function of Vertebrate and Invertebrate Active Zones / Craig C. Garner, Kang Shen 63

Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function / Deniz Atasoy, Ege T. Kavalali 91

The Molecular Machinery for Synaptic Vesicle Endocytosis / Peter S. McPherson, Brigitte Ritter, George J. Augustine 111

Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes / Zu-Hang Sheng, Amy Lee, William A. Catterall 147

Adhesion Molecules at the Synapse / Alaa El-Husseini 173

Dendritic Organelles for Postsynaptic Trafficking / Cyril Hanus, Michael D. Ehlers 205

Structure and Mechanism of Action of AMPA and Kainate Receptors / Mark L. Mayer 251

Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity / Jose A. Esteban 271

Structure and Function of the NMDA Receptor / Hongjie Yuan, Matthew T. Geballe, Kasper B. Hansen, Stephen F. Traynelis 289

Molecular Properties and Cell Biology of the NMDA Receptor / Robert J. Wenthold, Rana A. Al-Hallaq, Catherine Croft Swanwick, Ronald S. Petralia 317

Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses / Daniel Choquet, Antoine Triller 369

Scaffold Proteins in the Postsynaptic Density / Mary B. Kennedy, Edoardo Marcora, Holly J. Carlisle 407

Ca[superscript 2+] Signaling in Dendritic Spines / Bernardo L. Sabatini, Karel Svoboda 441

Postsynaptic Targeting of Protein Kinases and Phosphatases / Stefan Strack, Johannes W. Hell 459

Long-Term Potentiation / John E. Lisman, Johannes W. Hell 501

Homeostatic Synaptic Plasticity / Gina G. Turrigiano 535

Ubiquitin and Protein Degradation in Synapse Function / Thomas D. Helton, Michael D. Ehlers 553

Signaling from Synapse to Nucleus / Carrie L. Heusner, Kelsey C. Martin 601

Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses / I. Lorena Arancibia-Carcamo, Antoine Triller, Josef T. Kittler 621

Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology / John A. Wemmie, Xiang-ming Zha, Michael J. Welsh 661

Glia as Active Participants in the Development and Function of Synapses / Cagla Eroglu, Ben A. Barres, Beth Stevens 683

Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis / James O. McNamara, Yang Z. Huang, Enhui Pan 715

Stroke - A Synaptic Perspective / Robert Meller, Roger P. Simon 731

Neuroplasticity and Pathological Pain / Michael W. Salter 759.

Notes:

Includes bibliographical references and index.

ISBN:

9780387772318

0387772316

OCLC:

191243193