Dopamine transporters : chemistry, biology, and pharmacology / edited by Mark L. Trudell, Sari Izenwasser.

Format:

Book

Contributor:

Trudell, Mark L.

Izenwasser, Sari.

Series:

Wiley series in drug discovery and development

Language:

English

Subjects (All):

Dopamine.

Dopamine--Physiological effect.

Carrier proteins.

Dopamine Agents--metabolism.

Dopamine--physiology.

Dopamine Plasma Membrane Transport Proteins.

Dopamine Uptake Inhibitors--metabolism.

Medical Subjects:

Dopamine Agents--metabolism.

Dopamine--physiology.

Dopamine Plasma Membrane Transport Proteins.

Dopamine Uptake Inhibitors--metabolism.

Physical Description:

xii, 443 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 25 cm.

Place of Publication:

Hoboken, N.J. : Wiley, [2008]

Summary:

This book consolidates current information on the dopamine transporter (DAT) in relation to medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.

This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology: Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization, Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers, Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods. This is a hands-on reference for researchers, medicinal chemists, pharmacologists, and biologists working with DAT or related proteins and for students in related areas of study.

Contents:

The dopamine transporter: an anatomical perspective / Hilary R. Smith ... [et al.]

Dopamine transporter, disease states, and pathology / Deborah C. Mash

Cloning and genetic analysis of dopamine transporters / David J. Vandenbergh

Molecular structure and composition of dopamine transporters / M. Laura Parnas and Roxanne A. Vaughan

Electrochemical characterization of dopamine transporters / Evgeny A. Budygin and Sara R. Jones

Tropane-based dopamine transporter-uptake inhibitors / Scott P. Runyon and F. Ivy Carroll

The benztropines: atypical dopamine-uptake inhibitors that provide clues about cocaine's mechanism at the dopamine transporter / Amy Hauck Newman and Jonathan L. Katz

Structure-activity relationship of GBR 12909 ligands / Thomas E. Prisinzano and Kenner C. Rice

Structure-activity relationship study of piperidine derivatives for dopamine transporters / Prashant S. Kharkar, Aloke K. Dutta, and Maarten E.A. Reith

Non-nitrogen-containing dopamine transporter-uptake inhibitors / Peter C. Meltzer

Dopamine-releasing agents / Bruce E. Blough

PET/SPECT imaging studies of the plasma membrane dopamine transporter / Paul Cumming, Weiguo Ye, and Dean F. Wong

In vitro studies of dopamine transporter function and regulation / Brian R. Hoover, Bruce H. Mandt, and Nancy R. Zahniser

In vivo studies of dopamine transporter function / Jane B. Acri.

Notes:

Errata slip inserted.

Includes bibliographical references and index.

ISBN:

9780470117903

0470117907

OCLC:

181862653

Online:

Publisher description