Blood disorders in the elderly / edited by Lodovico Balducci, William Ershler, Giovanni de Gaetano.

Format:

Book

Contributor:

Balducci, Lodovico.

Ershler, William B.

De Gaetano, Giovanni.

Language:

English

Subjects (All):

Blood--Diseases.

Geriatrics.

Hematologic Diseases.

Aged.

Medical Subjects:

Hematologic Diseases.

Aged.

Physical Description:

xii, 484 pages, 14 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2008.

Summary:

The developed world has an increasingly aging population, with approximately 10% of the population aged over 65 years. As the incidence and prevalence of blood disorders increases with age, these conditions are a heavy burden on healthcare systems.

Blood Disorders in the Elderly will provide hematologists, geriatricians, and all clinicians involved in the care of patients with blood disorders with clear clinical advice on the diagnosis and management of these conditions.

The introductory section reviews epidemiology of aging and anemia and provides a comprehensive approach to the management of cancer in the aging patient. This is followed by a full discussion of hemopoiesis and changes it undergoes in aging. The remaining sections cover the diagnosis and management of all major disorders: anemia, malignancy, coagulation and platelet disorders, and hemophilia. A detailed chapter on antithrombotic therapies is also included.

Contents:

Part I Epidemiology

1 Epidemiology of aging / Lodovico Balducci, William B. Ershler 3

2 Epidemiology of anemia in older adults / Kushang V. Patel, Jack M. Guralnik 11

3 Cancer in the older person: a comprehensive approach / Oscar A. Cepeda, Julie K. Gammack, John E. Morley 21

4 From fitness to frailty: toward a nosologic classification of the older aged person / Lodovico Balducci, Claudia Beghe 39

Part II Hematopoiesis

5 Stem cell exhaustion and aging / Jeffrey Yates, Gary Van Zant 57

6 Hematopoietic microenvironment and age / David N. Haylock, Susan K. Nilsson 71

7 Replicative senescence, aging, and cancer / Rita B. Effros 84

8 Qualitative changes of hematopoiesis / France Laurencet 95

9 Aging and hematopoietic stress / Lodovico Balducci, Cheryl L. Hardy 120

10 Immunoglobulin response and aging / Yuping Deng, Stefan Gravenstein 129

11 Biological and clinical significance of monoclonal gammopathy / Arati V. Rao, Harvey Jay Cohen 138

Part III Anemia of aging

12 Erythropoietin and aging / Andrew S. Artz 157

13 Iron and aging / Elizabeta Nemeth, Tomas Ganz 171

14 Prevalence and mechanisms of B[subscript 12] deficiency / Sally P. Stabler 181

15 Consequences of chronic anemia in the older person / Lodovico Balducci 192

16 The pathogenesis of late-life anemia / Bindu Kanapuru, William B. Ershler 203

17 Treatment of late-life anemia / William B. Ershler 214

Part IV Hematologic malignancies and aging

18 Cancer chemotherapy in the older person / Lodovico Balducci 225

19 Acute myeloid leukemia in the elderly / Magda Melchert, Jeffrey Lancet 237

20 Acute lymphoblastic leukemia in the elderly patient: diagnosis and therapy / Salvador Bruno, Fermina Mazzella, Oscar Ballester 256

21 Multiple myeloma / Todd J. Alekshun, Melissa Alsina 272

22 Non-Hodgkin lymphoma / Nicole Jacobi, Bruce A. Peterson 290

23 Unusual lymphomas in the elderly / Youssef Gamal, Samuel Kerr, Thomas P. Loughran 311

24 Chronic lymphocytic leukemia in the elderly / Alexander S. D. Spiers 342

25 Polycythemia vera and idopathic myelofibrosis in the elderly / Jerry L. Spivak 370

Part V Disorders of hemostasis in the elderly

26 Acquired hemophilia in the elderly / Francesco Baudo, Francesco de Cataldo 387

27 Blood coagulation and aging / Jozef Vermylen, Marc F. Hoylaerts 406

28 Platelet disorders in the elderly / Laura Terranova, Giancarla Gerli, Marco Cattaneo 420

29 Gene-environment interactions and vascular risk in the elderly / Daniela Mari 434

30 Antithrombotic therapy: guidelines for the elderly / Chiara Cerletti, Holger Schunemann, Giovanni de Gaetano 448.

Notes:

Includes bibliographical references and index.

ISBN:

9780521875738

0521875730

OCLC:

144217904

Online:

Contributor biographical information

Publisher description