RNA and the regulation of gene expression : a hidden layer of complexity / edited by Kevin V. Morris.

Format:

Book

Contributor:

Morris, Kevin V.

Language:

English

Subjects (All):

RNA.

Genetic regulation.

Gene Expression Regulation.

Medical Subjects:

RNA.

Gene Expression Regulation.

Physical Description:

vii, 228 pages, 3 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

Norfolk : Caister Academic Press, [2008]

Summary:

The role of RNA in regulating gene expression has become a topic of intense interest. In this book internationally recognized experts in RNA research explore and discuss the methods whereby RNA can regulate gene expression with examples in yeast, Drosophila, mammals and viral infection, and highlight the application of this knowledge in therapeutics and research. Topics include gene silencing and gene activation, the hammerhead ribozyme, epigenetic regulation, RNAi, microRNA and pyknons. This comprehensive publication is intended for readers with teaching or research interests in RNA, the regulation of gene expression, genetics, genomics or molecular biology.

Contents:

1 The Hammerhead Ribozyme Revisited: New Biological Insights for the Development of Therapeutic Agents and for Reverse Genomics Applications / Justin Hean, Marc S. Weinberg 1

2 Epigenetic Regulation of Gene Expression / Kevin V. Morris 19

3 The Role of RNAi and Non-coding RNAs in Polycomb-mediated Control of Gene Expression and Genomic Programming / Manuela Portoso, Giacomo Cavalli 29

4 Heterochromatin Assembly and Transcriptional Gene Silencing under the Control of Nuclear RNAi: Lessons from Fission Yeast / Aurelia Vavasseur, Leila Touat-Todeschini, Andre Verdel 45

5 RNA-mediated Gene Regulation in Drosophila / Harsh H. Kavi, Harvey R. Fernandez, Weiwu Xie, James A. Birchler 59

6 MicroRNA-mediated Regulation of Gene Expression / Lena J. Chin, Frank J. Slack 73

7 Viral Infection-Related MicroRNAs in Viral and Host Genomic Evolution / Yoichi R. Fujii, Nitin K. Saksena 91

8 Regulation of Mammalian Mobile DNA by RNA-based Silencing Pathways / Harris Soifer 109

9 The Role of Non-coding RNAs in Controlling Mammalian RNA Polymerase II Transcription / Stacey D. Wagner, Jennifer F. Kugel, James A. Goodrich 133

10 Pyknons as Putative Novel and Organism-specific Regulatory Motifs / Isidore Rigoutsos 149

11 RNA-Mediated Recognition of Chromosomal DNA / David R. Corey 165

12 RNA-mediated Transcriptional Gene Silencing: Mechanism and Implications in Writing the Histone Code / Kevin V. Morris 173

13 Small RNA-mediated gene activation / Long-Cheng Li 189

14 Therapeutic Potential of RNA-mediated Control of Gene Expression: Options and Designs / L Scherer, JJ Rossi 201.

Notes:

Includes bibliographical references and index.

ISBN:

9781904455257

1904455255

OCLC:

170922279