Molecular epidemiology : applications in cancer and other human diseases / edited by Timothy R. Rebbeck, Christine B. Ambrosone, Peter G. Shields.

Format:

Book

Contributor:

Rebbeck, Timothy R.

Ambrosone, Christine B.

Shields, Peter G.

Language:

English

Subjects (All):

Cancer--Epidemiology.

Cancer.

Molecular epidemiology.

Disease susceptibility--Genetic aspects.

Disease susceptibility.

Neoplasms--epidemiology.

Neoplasms--genetics.

Molecular Epidemiology--methods.

Genetic Predisposition to Disease--epidemiology.

Genetic Predisposition to Disease--genetics.

Medical Subjects:

Neoplasms--epidemiology.

Neoplasms--genetics.

Molecular Epidemiology--methods.

Genetic Predisposition to Disease--epidemiology.

Genetic Predisposition to Disease--genetics.

Physical Description:

xi, 302 pages : illustrations ; 26 cm

Place of Publication:

New York : Informa Healthcare, [2008]

Summary:

This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring: design considerations in molecular epidemiology, including: case-only, family-based, approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics, incorporation of biomarkers in clinical trials, measurement issues in molecular epidemiology, including, DNA biosampling methods, principles for high-quality genotyping, haplotypes, biomarkers of exposure and effect, exposure assessment, methods of statistical inference used in molecular epidemiology, including, gene-gene and gene-environment interaction analysis, novel high-dimensional analysis approaches, pathway-based analysis methods, haplotype methods, dealing with race and ethnicity, risk models, a discussion of reporting and interpreting results. A specific discussion and synopsis of these methods provides concrete examples drawn from primary research in cancer.

Covering design considerations, measurement issues, and methods of statistical inference, and filled with scientific tables, equations, and pictures, Molecular Epidemiology: Applications in Cancer and Other Human Diseases presents a solid, single-source foundation for conducting and interpreting molecular epidemiological studies.

Contents:

Design considerations in molecular epidemiology / Monserrat García-Closas, Qing Lan, and Nathaniel Rothman

Family-based study designs / Audrey H. Schnell and John S. Witte

Trials and interventions in molecular epidemiology / James R. Marshall and Mary E. Reid

Molecular epidemiological designs for prognosis / Cornelia M. Ulrich and Christine B. Ambrosone

Biosampling methods / Regina M. Santella and Susan E. Hankinson

Principles for high-quality genotyping / Stephen J. Chanock

Biomarkers of exposure and effect / Christopher P. Wild

Questionnaire assessment / James R. Marshall

Pharmacogenetics in cancer chemotherapy / Xifeng Wu and Jian Gu

Human genetic variation and its implication in understanding "race"/ethnicity and admixture / Jill Barnholtz-Sloan, Indrani Halder, Mark Shriver

Statistical approaches to studies of gene-gene and gene-environment interactions / Nilanjan Chatterjee and Bhramar Mukherjee

Novel analytical methods for association studies / Jason H. Moore, Margaret R. Karagas, and Angeline S. Andrew

Pathway-based methods in molecular cancer epidemiology / Fritz F. Parl ... [et al.]

Haplotype association analysis / Peter Kraft and Jinbo Chen

Genomewide association studies / Michael B. Bracken, Andrew DeWan, and Josephine Hoh

Validation and confirmation of associations / John P.A. Ioannidis

Models of absolute risk: interpretation, estimation, validation, and application / Mitchell H. Gail

Reporting and interpreting results / Julian Little.

Notes:

Includes bibliographical references and index.

ISBN:

9781420052916

1420052918

OCLC:

190751482

Online:

Publisher description