Lung cancer : a practical guide / [edited by] Luis E. Raez, Orlando E. Silva.

Format:

Book

Contributor:

Ráez, Luis E.

Silva, Orlando E.

Language:

English

Subjects (All):

Lungs--Cancer--Handbooks, manuals, etc.

Lungs.

Lungs--Cancer.

Lung Neoplasms.

Medical Subjects:

Lung Neoplasms.

Genre:

Handbooks and manuals.

Physical Description:

xxi, 256 pages ; 22 cm

Place of Publication:

Edinburgh ; Philadelphia : Saunders Elsevier, 2008.

Summary:

He is a member of numerous scientific societies including the American Association of Cancer Research (AACR), American Society of Clinical Oncology (ASCO), American College of Physicians (ACP), American Society of Hematology (ASH), American College of Chest Physicians (ACCP), Colegio Medico del Peru (CMP), and International Association for the Study of Lung Cancer (IASLC).

He is a Fellow of the American College of Physicians, a Diplomat of the American Boards of Internal Medicine, Hematology, Oncology and Forensic Medicine. He graduated from Northwestern University Medical School in 1988, in Chicago, Illinois. He completed his residency in Internal Medicine at the University of Michigan in Ann Arbor, Michigan in 1991 and his fellowship in Hematology and Oncology at Duke University in Durham, North Carolina, in 1994. He is a member of the American Society of Clinical Oncology and other national and international medical societies.

In 2002 Dr Silva created the Inter American Breast Cancer Conference, which is held in Cancun, Mexico. The conference has turned into a world meeting focusing on 'what to do with your patient at the bedside. One of the objectives of the meeting is to create a bridge across the Altantic Ocean which will unite American and European physician/scientists. At this biannual meeting, Dr Silva established the Umberto Veronesi Award for Excellence in Breast Cancer Research and Development.

Contents:

1 History of lung cancer 1

3400 BC to 1774 AD 1

1775 to 1900 2

1900 to 2000 5

2 Epidemiology of lung Cancer 7

Risk factors associated with lung cancer 7

Lung cancer and race and ethnicity 9

Chemoprevention and lung cancer 10

Molecular changes associated with lung cancer development 10

Methylation, smoking, and lung cancer 11

K-ras, P53, and other changes in lung cancer 11

Tyrosine kinase inhibitors and lung cancer 12

3 Screening for lung cancer 13

Non-imaging methods for lung cancer screening 14

Imaging methods for lung cancer screening 15

Cost-effectiveness in lung cancer screening 17

Ongoing trials 18

4 Imaging in lung cancer 19

Chest radiography 19

Computerized tomography 25

Magnetic resonance imaging 26

Positron emission tomography 27

5 Diagnostic techniques in Lung cancer 32

Introduction 32

General approach 32

Sputum cytology 33

Flexible bronchoscopy 33

Transthoracic needle aspiration 34

Mediastinoscopy and mediastinostomy 34

Accuracy in differentiating non-small-cell and small-cell lung cancers 35

Esophageal, endoscopic, ultrasound-guided, fine needle aspiration 35

6 Lung pathology 36

Carcinoma 36

Squamous cell carcinoma 39

Small-cell carcinoma 40

Adenocarcinoma 42

Subtypes 43

Adenocarcinoma Variants 45

Carcinoid and related tumors 52

Other tumours 57

Adenoma 68

Papilloma 70

Lymphoma 71

7 Surgery in non-small-cell lung cancer 75

Types of surgical procedure 75

Pneumonectomy 76

Lobectomy via thoracothomy or video-assisted thoracoscopy 76

Video-assisted thoracoscopy and early-stage non-small-cell lung cancer 76

Bilobectomy 78

Lesser resection (segmentectomy, wedge resection, precision cautery dissection) vs lobectomy 78

Sublobar resection with adjuvant intraoperative brachytherapy 81

Bronchoplastic procedures 82

Mediastinal lymphadenectomy 82

Radiofrequency ablation 83

Stereotactic radiosurgery 88

Surgical morbidity and mortality in non-small-cell lung cancer 90

Surgical treatment of non-small-cell lung cancer based on TNM stage 90

Surgical treatment of stage I and stage II disease 91

T3N0 tumors 92

Stage IIIA disease 93

Surgery in stage IV lung cancer 94

8 Neoadjuvant therapy for non-small-cell lung cancer 97

Uses of neoadjuvant therapy 97

Randomized trials 97

Neoadjuvant chemotherapy trials with negative results 97

Neoadjuvant chemotherapy trials with positive results 98

Neoadjuvant chemotherapy with concurrent radiation therapy 102

Superior sulcus tumors (Pancoast tumor) 104

9 Adjuvant chemotherapy for non-small-cell lung cancer 106

10 Combined modality therapy for locally advanced non-small-cell lung cancer 111

Radiation therapy for non-small-cell lung cancer 111

Sequential chemotherapy followed by radiation therapy 112

Concomitant administraction of chemotherapy and radiotherapy for locally advanced disease 114

Induction or consolidation chemotherapy with concurrent chemoradio-therapy 117

How to include surgery with combined modality therapy 120

Future directions in the treatment of locally advanced non-small-cell lung cancer 122

11 Chemotherapy in advanced non-small-cell lung cancer 124

Prolongation of survival by chemotherapy 124

Improvement in quality of life 125

Development of platin-based regimens 126

Development of third-generation chemotherapy agents in the 1990s 127

Combination chemotherapy with third-generation agents is better than single agents alone 130

The best chemotherapeutic combination with third-generation agents for non-small-cell lung cancer 131

Non-platin combinations in non-small-cell lung cancer 135

Combination chemotherapy using 'triplets' (three agents) 138

Combination chemotherapy with targeted agents 138

Best combination chemotherapy 139

New chemotherapy agents for non-small-cell lung cancer 140

12 Surgery in small-cell lung cancer 149

Surgery in limited-disease small-cell lung cancer 149

Surgery after induction chemotherapy 151

Salvage surgery 152

13 Chemotherapy in limited-disease, small-cell lung cancer 153

14 Radiation therapy for limited-disease, small-cell lung cancer 156

Fallacies in study design 156

Why is thoracic radiation needed? 156

Sequencing of radiation therapy with chemotherapy 157

Early randomized trials: concurrent treatment 157

Early randomized trials: sequental treatment 158

Summary of early randomized trials 158

Summary of negative randomized trials 158

Meta-analyses 159

Early vs late thoracic radiation 159

Prophylactic cranial irradiation 161

15 Extensive-disease, small-cell lung cancer 165

Chemotherapy agents 165

First-line chemotherapy for extensive-disease, small-cell lung cancer 166

Second-ling therapy for extensive-disease, small-cell lung cancer 169

Other chemotherapeutic options for extensive-disease, small-cell lung cancer 172

16 Malignant mesothelioma 173

Epidemiology 173

Prognostic factors 174

Role of surgery 175

Radiotherapy 178

Chemotherapy for mesothelioma 179

17 Lung cancer in the elderly population and poor performance status 182

Age as a prognostic factor 182

Guidelines from the National Comprehensive Cancer Network 183

Best supportive care vs single-agent chemotherapy 183

Platinum-based combination therapy in elderly patients with non-small-cell lung cancer 186

Take-Home messages: elderly vs 'poor risk' patients with advanced non-small-cell lung cancer 192

18 Targeted therapy in non-small-cell lung cancer 193

Introduction 193

Approved compounds for non-small-cell lung cancer and mechanism of action 194

Epidermal growth factor receptor 194

Gefitinib 194

Erlotinib 196

Where are we going with the molecular markers for tyrosine Kinase inhibitors? 199

Compounds in clinical development for therapy for non-small-cell lung cancer 199

19 Vaccine therapy in lung cancer 209

Introduction 209

General steps of immune tolerance and suppression in cancer 209

Types of vaccine according to their manufacturing process 210

Tumor vaccines used in lung cancer 210

20 Palliative treatment in lung cancer 223

Anemia and lung cancer 223

Nausea and vomiting 226

Febrile neutropenia 229

21 Lung cancer in women 236

Introduction 236

Lung cancer and smoking in women 237

Risk factors for female smokers 237

Reducing prevalence of smoking among women 238

Other factors linked to women with lung cancer 238

Epidermal growth factor receptor and lung cancer 241

Hormonal influences in women with lung cancer 242

The role of genetics 243

Prognosis of women with lung cancer 244.

Notes:

Includes bibliographical references and index.

ISBN:

9780702028892

0702028894

OCLC:

181359058