Retinal and choroidal angiogenesis / edited by J. S. Penn.

Format:

Book

Contributor:

Penn, J. S. (John S.)

Language:

English

Subjects (All):

Neovascularization.

Retina--Diseases.

Retina.

Choroid--Diseases.

Choroid.

Eye--Blood-vessels.

Eye.

Retinal Neovascularization.

Choroidal Neovascularization.

Medical Subjects:

Retinal Neovascularization.

Choroidal Neovascularization.

Physical Description:

xxii, 557 pages : illustrations (some color) ; 24 cm

Place of Publication:

Dordrecht ; London : Springer, 2008.

Summary:

Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries. For this reason, ocular angiogenesis is an intensely studied process, and the field is advancing at an astounding pace. It has become increasingly difficult to manage the vast amount of information generated by the growing group of interested investigators, thus a resource is needed that distills and summarizes our progress to date. Retinal and Choroidal Angiogenesis provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Renowned academic scientists, pharmaceutical scientists, and clinician-scientists have contributed chapters identifying the cellular and molecular mechanisms of retinal and choroidal angiogenesis; defining animal models of these pathologic processes; or describing the application of current tools, techniques, and theories to disease pathogenesis in humans suffering from conditions characterized by ocular angiogenesis. Additionally, novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. Retinal and Choroidal Angiogenesis emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance. The result is a reference work appealing to ophthalmologists interested in clinical applications, as well as to basic scientists interested in the cellular and molecular mechanisms of angiogenesis, both in the context of ocular and non-ocular conditions.

Contents:

Angiogenesis Study Models

1 Cellular and Molecular Mechanisms of Retinal Angiogenesis / M. A. Behzadian, M. Bartoli, A. B. El-Remessy, M. Al-Shabrawey, D. H. Platt, G. I. Liou, R. W. Caldwell, R. B. Caldwell 1

2 Animal Models of Choroidal Neovascularization / M. L. Clark, J. A. Fowler, J. S. Penn 41

3 Rodent Models of Oxygen-Induced Retinopathy / S. E. Yanni, G. W. McCollum, J. S. Penn 57

4 Animal Models of Diabetic Retinopathy / T. S. Kern 81

5 Neovascularization in Models of Branch Retinal Vein Occlusion / R. P. Danis, D. P. Bingaman 103

Molecular Characterization

6 Vasculogenesis and Angiogenesis in Formation of the Human Retinal Vasculature / T. Chan-Ling 119

7 IGF-1 and Retinopathy / L. E. H. Smith 139

8 Hypoxia and Retinal Neovascularization / B. A. Berkowitz 151

9 Hypoxia Inducible Factor-1 and VEGF Induction / A. Madan 169

10 The Role of Protein Kinase C in Diabetic Retinal Vascular Abnormalities / J. K. Sun, G. L. King 187

11 Eph Receptor Tyrosine Kinases: Modulators of Angiogenesis / J. Chen, D. Brantley-Siders, J. S. Penn 203

12 Adenosine in Retinal Vasculogenesis and Angiogenesis in Oxygen-Induced Retinopathy / G. A. Lutty, D. S. McLeod 221

13 The Regulation of Retinal Angiogenesis by Cyclooxygenase and the Prostanoids / G. W. McCollum, J. S. Penn 241

14 Extracellular Proteinases in Ocular Angiogenesis / A. Das, P. G. McGuire 259

15 Oxygen-Independent Angiogenic Stimuli / J. M. Holmes, D. A. Leske, W. L. Lanier 279

16 Growth Factor Synergy in Angiogenesis / A. V. Ljubimov 289

17 Pigment Epithelium-Derived Factor and Angiogenesis / J. Amaral, S. P. Becerra 311

18 Circulating Endothelial Progenitor Cells and Adult Vasculogenesis / S. Caballero, N. Sengupta, L. C. Shaw, M. B. Grant 339

Applications to Clinical Conditions

19 Retinopathy of Prematurity / D. L. Phelps 363

20 Angiogenesis in Sickle Cell Retinopathy / G. A. Lutty, D. S. McLeod 389

21 Diabetic Retinopathy / R. N. Frank 407

22 Systems for Drug Delivery to the Posterior Segment of the Eye / A. L. Weiner, D. A. Marsh 419

23 Novel Therapeutic Strategies for Posterior Segment Neovascularization / D. P. Bingaman, X. Gu, A. M. Timmers, A. Davis 445

24 Choroidal Neovascularization in Age-Related Macular Degeneration-From Mice to Man / L. Berglin 527.

Notes:

"The contents of this book are based on the proceedings of the Retinal and Choroidal Angiogenesis Symposium, held at Vanderbilt University on October 15 and 16, 2004."--P. ix.

Includes bibliographical references and index.

ISBN:

9781402067792

1402067798

OCLC:

174130525