Innate and adaptive immunity in the tumor microenvironment / Eitan Yefenof, editor.

Format:

Book

Contributor:

Yefenof, Eitan.

Series:

Tumor microenvironment ; 1.

The tumor microenvironment ; 1

Language:

English

Subjects (All):

Cancer cells.

Tumors.

Natural immunity.

Neoplasms--microbiology.

Antigens, Neoplasm.

Antibodies, Neoplasm.

Immunity, Innate.

Medical Subjects:

Neoplasms--microbiology.

Antigens, Neoplasm.

Antibodies, Neoplasm.

Immunity, Innate.

Physical Description:

xii, 212 pages : illustrations (partly color) ; 25 cm.

Place of Publication:

[Dordrecht] : Springer, [2008]

Summary:

Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.

Contents:

1 Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression / Theresa L. Whiteside 1

2 Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor Cells / Soldano Ferrone, Theresa L. Whiteside 35

3 Local Tumor Growth and Spontaneous Systemic T Cell Responses in Cancer Patients: A Paradox and Puzzle / Philipp Beckhove, Volker Schirrmacher 53

4 Insights into Mechanisms of Immune Resistance in the Tumor Microenvironment through Molecular Profiling / Thomas F. Gajewski 77

5 Tumor Antigens as Modulators of the Tumor Microenvironment / Katja Engelmann, Olivera J. Finn 91

6 Tumor Cell Resistance to Apoptosis by Infiltrating Cytotoxic Lymphocytes / Benjamin Bonavida 121

7 The Tumor Microenvironment as a Model for Tissue-Specific Rejection / Silvia Selleri, Sara Deola, Cristiano Rumino, Francesco M. Marincola 139

8 Functional Cytotoxicity of T Cells in the Tumor Microenvironment / Michal Lotem, Arthur Machlenkin, Shoshana Frankenburg, Tamar Peretz 157

9 Natural Killer Cells at the Tumors Microenvironment / Roi Gazit, Ofer Mandelboim 171

10 Contribution of the Microenvironment to the Pathogenesis of EBV-Positive Hodgkin and Nasal NK/T-cell Lymphomas / Eva Klein, Miki Takahara, Lorand Levente Kis 195.

Notes:

Includes bibliographical references and index.

ISBN:

9781402067495

1402067496

140206750X

9781402067501

OCLC:

180474025