Science and psychiatry : groundbreaking discoveries in molecular neuroscience / by Solomon H. Snyder ; foreword by Eric R. Kandel ; commentaries by Eric J. Nestler ... [and others].

Format:

Book

Author/Creator:

Snyder, Solomon H., 1938-

Language:

English

Subjects (All):

Molecular neurobiology.

Neurochemistry.

Receptors, Neurotransmitter--drug effects.

Receptors, Neurotransmitter--physiology.

Apoptosis--physiology.

Neurochemistry--methods.

Psychotropic Drugs--pharmacokinetics.

Psychotropic Drugs--therapeutic use.

Medical Subjects:

Receptors, Neurotransmitter--drug effects.

Receptors, Neurotransmitter--physiology.

Apoptosis--physiology.

Neurochemistry--methods.

Psychotropic Drugs--pharmacokinetics.

Psychotropic Drugs--therapeutic use.

Physical Description:

xxxv, 477 pages : illustrations (partly color) ; 24 cm

Edition:

First edition.

Place of Publication:

Washington, DC : American Psychiatric Pub., [2008]

Contents:

Foreword: Sol Snyder: Audacious Scientist, Leader of the Scientific Community, and Remarkable Human Being! / Eric R. Kandel xv

Part I Discovery and Characterization of the Opiate Receptor

Commentary: Radioligand Binding Methodologies: New Inventions, New Directions / Eric J. Nestler 3

1 Opiate Receptor: Demonstration in Nervous Tissue / Candace B. Pert, Solomon H. Snyder 9

2 Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain / Candace B. Pert, Gavril Pasternak, Solomon H. Snyder 19

3 Historical Review: Opioid Receptors / Solomon H. Snyder, Gavril W. Pasternak 27

Part II Characterization of the Enkephalins

Commentary: The Discovery of Endogenous Opiates and Their Receptors: A Snyderian Saga of Skill and Judgment / Charles B. Nemeroff 49

4 Opiate Receptor in Normal and Drug Altered Brain Function / Solomon H. Snyder 53

5 Morphine-Like Peptides in Mammalian Brain: Isolation, Structure Elucidation, and Interactions With the Opiate Receptor / Rabi Simantov, Solomon H. Snyder 69

6 Opioid Peptide Enkephalin: Immunohistochemical Mapping in Rat Gentral Nervous System / Rabi Simantov, Michael J. Kuhar, George R. Uhl, Solomon H. Snyder 81

Part III Dopamine Receptors and Influences of Neuroleptics

Commentary: Dopamine Receptor Binding and Its Therapeutics / George Aghajanian 97

7 Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs / Ian Creese, David R. Burt, Solomon H. Snyder 103

8 Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain / David R. Burt, Ian Creese, Solomon H. Snyder 113

9 Dopamine Receptors, Neuroleptics, and Schizophrenia / Solomon H. Snyder 121

Part IV Drug Effects Explained as Actions on Neurotransmitter Receptors

Commentary: Perspectives on Simplicity and Discovery / Carol A. Tamminga 133

10 Antischizophrenic Drugs and Brain Cholinergic Receptors: Affinity for Muscarinic Sites Predicts Extrapyramidal Effects / Solomon Snyder, David Greenberg, Henry I. Yamamura 137

11 Tricyclic Antidepressants: Therapeutic Properties and Affinity for [alpha]-Noradrenergic Receptor Binding Sites in the Brain / David C. U'Prichard, David A. Greenberg, Peter P. Sheehan, Solomon H. Snyder 147

Part V Drug Actions and Serotonin Receptor Subtypes

Commentary: Clinical Data Stimulation of Basic Research: The Far-Reaching Clinical Significance of Serotonin Receptor Subtype Identification / Herbert Y. Meltzer 157

12 Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding / Stephen J. Peroutka, Solomon H. Snyder 163

13 Two Distinct Central Serotonin Receptors With Different Physiological Functions / Stephen J. Peroutka, Richard M. Lebovitz, Solomon H. Snyder 171

Part VI Inositol Phosphates and Actions of Lithium

Commentary: Lithium, Second Messengers, and Downstream Effects / Robert M. Post 181

14 Lithium Blocks a Phosphoinositide-Mediated Cholinergic Response in Hippocampal Slices / Paul F. Worley, William A. Heller, Solomon H. Snyder, Jay M. Baraban 189

15 Solubilization, Purification, and Characterization of an Inositol Trisphosphate Receptor / Surachai Supattapone, Paul F. Worley, Jay M. Baraban, Solomon H. Snyder 195

16 Second Messenger Systems and Psychoactive Drug Action: Focus on the Phosphoinositide System and Lithium / Jay M. Baraban, Paul F. Worley, Solomon H. Snyder 209

17 Purified Inositol 1,4,5-Trisphosphate Receptor Mediates Calcium Flux in Reconstituted Lipid Vesicles / Christopher D. Ferris, Richard L. Huganir, Surachai Supattapone, Solomon H. Snyder 231

Part VII Nitric Oxide as a Neurotransmitter

Commentary: Just Say "Yes": Snyder's Approach to the Difficult Problem of NO / Anne Young 243

18 Nitric Oxide Mediates Glutamate-Linked Enhancement of cGMP Levels in the Cerebellum / David S. Bredt, Solomon H. Snyder 249

19 Cloned and Expressed Nitric Oxide Synthase Structurally Resembles Cytochrome P-450 Reductase / David S. Bredt, Paul M. Hwang, Charles E. Glatt, Charles Lowenstein, Randall R. Reed, Solomon H. Snyder 261

20 Behavioral Abnormalities in Male Mice Lacking Neuronal Nitric Oxide Synthase / Randy J. Nelson, Gregory E. Demas, Paul L. Huang, Mark C. Fishman, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder 277

Part VIII d-Amino Acids as Neurotransmitters

Commentary: Disruptive Science: Incongruent Findings Lead to Novel Insights Into How the Brain Works / Joseph T. Coyle 291

21 d-Aspartate Localizations Imply Neuronal and Neuroendocrine Roles / Michael J. Schell, Odelia B. Cooper, Solomon H. Snyder 297

22 Serine Racemase: A Glial Enzyme Synthesizing d-Serine to Regulate Glutamate-N-Methyl-d-Aspartate Neurotransmission / Herman Wolosker, Seth Blackshaw, Solomon H. Snyder 313

23 Serine Racemase: Activation by Glutamate Neurotransmission via Glutamate Receptor Interacting Protein and Mediation of Neuronal Migration / Paul M. Kim, Hiroyuki Aizawa, Peter S. Kim, Alex S. Huang, Sasrutha R. Wickramasinghe, Amir H. Kashani, Roxanne K. Barrow, Richard L. Huganir, Anirvan Ghosh, Solomon H. Snyder 329

Part IX Neural Messengers of Cell Life and Death

Commentary: Beyond Neurotransmitters / Samuel Barondes 351

24 Cytochrome c Binds to Inositol 1,4,5-Trisphosphate Receptors, Amplifying Calcium-Dependent Apoptosis / Darren Boehning, Randen L. Patterson, Leela Sedaghat, Natalia O. Glebova, Tomohiro Kurosaki, Solomon H. Snyder 355

25 Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle / Thomas W. Sedlak, Solomon H. Snyder 383

26 S-Nitrosylated GAPDH Initiates Apoptotic Cell Death by Nuclear Translocation Following Siah1 Binding / Makoto R. Hara, Nishant Agrawal, Sangwon F. Kim, Matthew B. Cascio, Masahiro Fujimuro, Yuji Ozeki, Masaaki Takahashi, Jaime H. Cheah, Stephanie K. Tankou, Lynda D. Hester, Christopher D. Ferris, S. Diane Hayward, Solomon H. Snyder, Akira Sawa 399

Part X What Makes for Creative Discovery in Science?

Commentary: What Creates Creative Science and Scientists? / Nancy C. Andreasen 435

27 The Audacity Principle in Science / Solomon H. Snyder 439.

Notes:

Includes bibliographical references and index.

ISBN:

9781585622733

1585622737

OCLC:

181359076